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Skepinone-L

Skepinone-L structure

CAS No:
1221485-83-1
Formula:
C24H21F2NO4
Chemical Name:
Skepinone-L
Synonyms:
5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-;Skepinone-L, >=98%;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;Skepinone-L;2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
Categories:
Biochemical Engineering > Inhibitors

Description

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. IC50 value:Target: p38MAPKskepinone-L, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.

Skepinone-L Basic Attributes

Molecular Weight：

425.4246464

Exact Mass：

425.143860

DSSTox ID：

DTXSID30669907

Characteristics

PSA：

78.8

XLogP3：

4.95

Density：

1.384±0.06 g/cm3(Predicted)

Boiling Point：

629.0±55.0 °C(Predicted)

Flash Point：

334.2±31.5 °C

Refractive Index：

1.646

Drug Information

MeSH Entry Terms：

CBS3830

Computed Properties

Molecular Weight:425.4
XLogP3:4.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:425.14386448
Monoisotopic Mass:425.14386448
Topological Polar Surface Area:78.8
Heavy Atom Count:31
Complexity:608
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Skepinone-L

CAS No.: 1221485-83-1

Content: 0.98%

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