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AZ 628

AZ 628 structure

CAS No:
878739-06-1
Formula:
C27H25N5O2
Chemical Name:
AZ 628
Synonyms:
3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ-628;AZ628/AZ-628;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben;AZD628;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AZ628, >=99%;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
Categories:
Biochemical Engineering > Inhibitors

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Description

AZ628 is a pan-Raf kinase inhibitor with IC50s of 105, 34 and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively.

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide is a member of benzamides.

AZ 628 Basic Attributes

Molecular Weight：

451.5197

Exact Mass：

451.200836

UNII：

560S6B5D79

DSSTox ID：

DTXSID70236677

HScode：

2933990090

Characteristics

PSA：

97.6

XLogP3：

2.78

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Refractive Index：

1.638

Water Solubility：

DMSO: soluble10mg/mL, clear

Storage Conditions：

-20°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

25-36/37/38

safety instructions：

26-36/37/39-45

Marks：

Precautionary statement(s)：

P261-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H319-H335

Drug Information

MeSH Entry Terms：

AZ-628

Computed Properties

Molecular Weight:451.5
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:451.20082506
Monoisotopic Mass:451.20082506
Topological Polar Surface Area:97.6
Heavy Atom Count:34
Complexity:845
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of AZ 628

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

AZ 628

SDS

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