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GW9508

GW9508 structure

CAS No:
885101-89-3
Formula:
C22H21NO3
Chemical Name:
GW9508
Synonyms:
GW9508;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid;3-(4-((3-Phenoxybenzyl)aMino)phenyl)propanoic acid;Benzenepropanoic acid, 4-[[(3-phenoxyphenyl)methyl]amino]-;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acidGW9508;GW 95084-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid;4-(3-Phenoxybenzylamino)phenylpropionic acid;GW9508, >=99%
Categories:
Biochemical Engineering > Inhibitors

Description

GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.IC50 value: 7.32 (pEC50) [1]Target: GPR40GW9508 is shown to be at least 100-fold selective against 220 other GPCRs, 60 kinases, 63 proteases, seven integrins and 20 nuclear receptors including PPARα, δ and γ (pEC50 4.0, 4 and 4.9, respectively). GW9508 produces a concentration-dependent increase in intracellular Ca2+ c

GW9508 Basic Attributes

Molecular Weight：

347.412

Exact Mass：

347.152130

Characteristics

PSA：

58.6

XLogP3：

4.7

Density：

1.2±0.1 g/cm3

Flash Point：

279.4±28.7 °C

Refractive Index：

1.641

Water Solubility：

DMSO: >20mg/mL

Storage Conditions：

Store at RT

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

22-37/38-41-50/53

safety instructions：

26-39-60-61

Marks：

Xn,N

Precautionary statement(s)：

P261-P273-P280-P305 + P351 + P338-P501

Hazard Statements：

H302-H315-H318-H335-H410

GW9508 Use and Manufacturing

Methods of Manufacturing

Compound XV, 3-(4-(3-phenoxy-benzylamino)phenyl) propionic acid. Representative procedure where n = 1 , Z = H, X = NH and Y = 3-C

Uses

GW9508 is a GPR40 full agonist, used to regulate glucose in rats. Can be applied to the treatment of diabetes type 2. GPR120 selective and potent agonist also used in the treatment of diabetes type 2 due to GPR120—ability to mediate GLP-1 secretion, insulin sensitization and anti-obesity effects.

Recommended Suppliers of GW9508

Wuhan Pnq Int Trade Co., Ltd Contact Supplier

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GW9508, CAS:885101-89-3

Unit Price: $10-11 /G FOB

CAS No.: 885101-89-3

Grade: Chemical Grade

Content: 99%

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Compound Net Biotechnology Inc. Contact Supplier

CN
2 YRS

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

885101-89-3 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid

CAS No.: 885101-89-3

Grade: Industrial Grade

Content: 95%

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