 Home > Encyclopedia > PF 543

PF 543

PF 543 structure

CAS No:
1415562-82-1
Formula:
C27H31NO4S
Chemical Name:
PF 543
Synonyms:
PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-
Categories:
Biochemical Engineering > Inhibitors

Description

PF-543 is a novel cell-permeant inhibitor of SPHK1 with a Ki of 4.3 nM and more than 100-fold selectivity for SPHK1 over SPHK2.

[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]-2-pyrrolidinyl]methanol is a sulfonamide.

PF 543 Basic Attributes

Molecular Weight：

465.60434

Exact Mass：

465.197388

DSSTox ID：

DTXSID90735359

Characteristics

PSA：

75.2

XLogP3：

4.16

Density：

1.2±0.1 g/cm3

Boiling Point：

666.0±55.0 °C at 760 mmHg

Flash Point：

356.6±31.5 °C

Refractive Index：

1.610

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

1-((4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)phenyl)methyl)-2R-pyrrolidinemethanol

Computed Properties

Molecular Weight:465.6
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:465.19737964
Monoisotopic Mass:465.19737964
Topological Polar Surface Area:75.2
Heavy Atom Count:33
Complexity:679
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of PF 543

Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

PF-543

CAS No.: 1415562-82-1

Content: 0.999%

Inquiry