4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
-
![4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/4c17d708922b4c54b4accfd1480cbe9e.png "4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol")
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
structure -
-
CAS No:
312636-16-1
-
Formula:
C15H11ClN2OS
-
Chemical Name:
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
-
Synonyms:
Phenol,4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-;4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol;SKI 2
- Categories:
-
CAS No:
Description
SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.IC50 value: 78/45 μM (SK1/2) [2]Target: SKin vitro: SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II also reduces the expression of c-Myc and cyclin D1, the downstream target genes of the Wnt signaling pathway. SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II promotes the degradation of β
4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol is a substituted aniline.
Characteristics
73.4
4.8
off-white solid
1.4±0.1 g/cm3
507.1±60.0°C at 760 mmHg
260.5±32.9 °C
1.709
DMSO: ≥20 mg/mL
2-8°C
Computed Properties
Molecular Weight:302.8
XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:302.0280618
Monoisotopic Mass:302.0280618
Topological Polar Surface Area:73.4
Heavy Atom Count:20
Complexity:304
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
-
![United States]()
US
6 YRS
Business licensed Certified factoryManufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates
Latest News on 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
Dabrafenib
1195765-45-7
-
BOC-VAL-VAL-OH
69209-73-0
-
BMS 303141
943962-47-8
-
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanamide Formula
60117-17-1
-
(2S)-2-acetamido-6-amino-N-[(2S)-2-amino-3-methylbutanoyl]-N-propylhexanamide Formula
57899-96-4
-
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea Formula
26130-02-9
-
L-Tyrosyl-L-phenylalanine Structure
17355-11-2
-
C-REACTIVE PROTEIN FRAGMENT 77-82 Structure
130349-01-8
-
What is Sildenafil
139755-83-2
-
What is Dacomitinib
1110813-31-4
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
SDSRequest for Quotation