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Mozavaptan

Mozavaptan structure

CAS No:
137975-06-5
Formula:
C27H29N3O2
Chemical Name:
Mozavaptan
Synonyms:
Benzamide,N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-;1H-1-Benzazepine,benzamide deriv.;N-[4-[[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methylbenzamide;OPC 31260;Mozavaptan;137976-84-2
Categories:
Biochemical Engineering > Inhibitors

Description

Mozavaptan is an oral vasopressin V2 antagonist that has been launched in Japan for inappropriate antidiuretic hormone secretion syndrome (IADHS), an affliction manifesting as hyponatremia. It joins another nonpeptidic benzazepine, conivaptan, which corrects sodium and water imbalance by blocking the renal V2 receptor resulting in enhanced diuresis, thereby effectively increasing serum sodium concentration. While conivaptan inhibits both V1 and V2 receptors, mozavaptan is significantly mo

Mozavaptan is a member of benzamides.

Mozavaptan Basic Attributes

Molecular Weight：

427.54

Exact Mass：

427.54

EC Number：

1312995-182-4

DSSTox ID：

DTXSID8057641

Characteristics

PSA：

52.6

XLogP3：

4.5

Density：

1.2±0.1 g/cm3

Boiling Point：

543.0±50.0°C at 760 mmHg

Flash Point：

282.2±30.1 °C

Refractive Index：

1.647

Drug Information

MeSH：

Endogenous compounds and drugs that inhibit or block the activity of ANTIDUIRETIC HORMONE RECEPTORS. (See all compounds classified as Antidiuretic Hormone Receptor Antagonists.)

MeSH Entry Terms：

5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl)-2,3,4,5-tetrahydro-1H-benzazepine

Mozavaptan Use and Manufacturing

vasopressin V2 receptor antagonist

Computed Properties

Molecular Weight:427.5
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:427.22597718
Monoisotopic Mass:427.22597718
Topological Polar Surface Area:52.6
Heavy Atom Count:32
Complexity:643
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Mozavaptan 99% see COA Kanbei kanbei

CAS No.: 137975-06-5

Grade: Industrial Grade

Content: 99%

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