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SGI-1776

SGI-1776 structure

CAS No:
1025065-69-3
Formula:
C20H22F3N5O
Chemical Name:
SGI-1776
Synonyms:
SGI-1776;SGI-1776 free base;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amineSGI-1776;SGI-1776, >=98%;SGI-1776 free baseN-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-am
Categories:
Biochemical Engineering > Inhibitors

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Description

SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

SGI-1776 Basic Attributes

Molecular Weight：

405.4167896

Exact Mass：

405.177643

Characteristics

PSA：

54.7

XLogP3：

4.3

Density：

1.37

Refractive Index：

1.613

SGI-1776 Use and Manufacturing

Methods of Manufacturing

12. Scheme for the Synthesis of 7-29 . Scheme 613. Synthesis of N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy) phenyl imidazofi , 2-blpyridazin-6-amine (Compound 7-29):[0148] To the toluene (5 mL) solvent was added 7-12 (40 mg, 0.128 mmol), (1-methylpiperidin-4-yl)methanamine (24.53 0.191 mmol), ligand (7.53 mg, 0.019 mmol), Pd

Uses

A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.

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SGI-1776 free base

CAS No.: 1025065-69-3

Content: 99%

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