2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
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2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
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CAS No:
627536-09-8
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Formula:
C17H10ClFN6
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Chemical Name:
2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
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Synonyms:
SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-;2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;SCI 208;2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
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CAS No:
Description
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.
2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine Basic Attributes
352.7529032
352.063965
DTXSID60438042
Characteristics
76.5
3
off-white to tan
1.5±0.1 g/cm3
460.4°C at 760 mmHg
232.2±28.7 °C
1.717
DMSO: >5mg/mL
2-8°C
Safety Information
NONH for all modes of transport
3
22
Xn
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:352.8
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:352.0639502
Monoisotopic Mass:352.0639502
Topological Polar Surface Area:76.5
Heavy Atom Count:25
Complexity:437
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
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