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Stattic

Stattic structure

CAS No:
19983-44-9
Formula:
C8H5NO4S
Chemical Name:
Stattic
Synonyms:
Benzo[b]thiophene,6-nitro-,1,1-dioxide;6-Nitrobenzo[b]thiophene 1,1-dioxide;Stattic
Categories:
Biochemical Engineering > Inhibitors

Description

Stattic is a potent inhibitor of STAT3 activation and dimerization.

Stattic is a member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma. It has a role as an antineoplastic agent, a STAT3 inhibitor and a radiosensitizing agent. It is a member of 1-benzothiophenes, a C-nitro compound and a sulfone.

Stattic Basic Attributes

Molecular Weight：

211.19

Exact Mass：

211.19

DSSTox ID：

DTXSID70381575

HScode：

2934999090

Characteristics

PSA：

88.3

XLogP3：

0.7

Appearance：

white to beige

Density：

1.621±0.06 g/cm3(Predicted)

Melting Point：

187-188 °C

Boiling Point：

461.1±45.0 °C(Predicted)

Flash Point：

232.6±28.7 °C

Refractive Index：

1.671

Water Solubility：

DMSO: >20mg/mL

Storage Conditions：

Store at +4°C

Vapor Pressure：

3.04E-08mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38-22

safety instructions：

26-36/37/39

Marks：

Xi,Xn

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

stattic

Stattic Use and Manufacturing

Stattic is a Stat3 inhibitor which exhibited potent anti-tumor and induced chemo- and radio-sensitivity in nasopharyngeal carcinoma.

Computed Properties

Molecular Weight:211.20
XLogP3:0.7
Hydrogen Bond Acceptor Count:4
Exact Mass:210.99392881
Monoisotopic Mass:210.99392881
Topological Polar Surface Area:88.3
Heavy Atom Count:14
Complexity:375
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes