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5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine structure

CAS No:
935666-88-9
Formula:
C14H14ClFN8
Chemical Name:
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Synonyms:
5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD 1480;(S)-5-chloro-N4-(5-Methyl-1H-pyrazol-3-yl)-N2-(1-(5-MethylpyriMidin-2-yl)ethyl)pyriMidine-2,4-diaMine;(S)-5-chloro-N2-(1-(5-fluoropyriMidin-2-yl)ethyl)-N4-(5-Methyl-1H-pyrazol-3-yl)pyriMidine-2,4-diaMine;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamineAZD 1480;AZD 1480 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD1480, >=98%;(S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-
Categories:
Biochemical Engineering > Inhibitors

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Description

AZD-1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of < 0.4 nM, selectively against JAK3 and Tyk2, and to a smaller extent against JAK1.

AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.

5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine Basic Attributes

Molecular Weight：

348.7659632

Exact Mass：

348.101410

UNII：

KL2Z2TLF01

DSSTox ID：

DTXSID50239469

HScode：

29335990

Characteristics

PSA：

104

XLogP3：

2.4

Density：

1.5±0.1 g/cm3

Flash Point：

301.7±32.9 °C

Refractive Index：

1.702

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P301+P310, P308+P313, P314, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P310, P308+P313, P314, P321, P330, P405, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Computed Properties

Molecular Weight:348.76
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:348.1013983
Monoisotopic Mass:348.1013983
Topological Polar Surface Area:104
Heavy Atom Count:24
Complexity:397
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

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