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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE structure

CAS No:
545380-34-5
Formula:
C22H20N4O
Chemical Name:
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
Synonyms:
QNZ;N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine;QNZ (EVP4593);EVP 4593;EVP4593;EVP-4593;4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-;4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
Categories:
Biochemical Engineering > Inhibitors

Description

QNZ shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC channel.

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Basic Attributes

Molecular Weight：

356.42

Exact Mass：

356.163696

DSSTox ID：

DTXSID00333507

HScode：

2933990090

Characteristics

PSA：

73.1

XLogP3：

4.7

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Melting Point：

169-175°C

Boiling Point：

602°C at 760 mmHg

Flash Point：

317.9±31.5 °C

Refractive Index：

1.714

Water Solubility：

DMSO: soluble15mg/mL, clear

Storage Conditions：

Refrigerator, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

EVP 4593

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Use and Manufacturing

QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.

Computed Properties

Molecular Weight:356.4
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:356.16371127
Monoisotopic Mass:356.16371127
Topological Polar Surface Area:73.1
Heavy Atom Count:27
Complexity:434
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 545380-34-5

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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI 99% white powder kanbei

CAS No.: 545380-34-5

Grade: Industrial Grade

Content: 99%

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Guide of 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

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