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Linifanib

Linifanib structure

CAS No:
796967-16-3
Formula:
C21H18FN5O
Chemical Name:
Linifanib
Synonyms:
Urea,N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)-;N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea;ABT 869;Linifanib;Linigfanib;RG 3635;AL 39324;1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea;1148026-94-1
Categories:
Biochemical Engineering > Inhibitors

Description

Linifanib (ABT-869) is a multi-targeted inhibitor of VEGF and PDGFR receptor family with IC50s of 3, 4, 66, 4 nM for KDR, Flt-1, PDGFRβ and FLT3, respectively.

Linifanib Basic Attributes

Molecular Weight：

375.405

Exact Mass：

375.40

Characteristics

PSA：

95.8

XLogP3：

3.9

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Melting Point：

209-211 °C

Boiling Point：

542.203ºC at 760 mmHg

Flash Point：

281.7±30.1 °C

Refractive Index：

1.766

Storage Conditions：

-20°C Freezer

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P273, P281, P308+P313, P314, P391, P405, P501

Hazard Statements：

H361

Linifanib Use and Manufacturing

An oral tyrosine kinase inhibitor with antineoplasic activity.

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Linifanib(ABT-869)

CAS No.: 796967-16-3

Content: 99%

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