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DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE structure

CAS No:
108549-23-1
Formula:
C20H28NO2P
Chemical Name:
DIBENZYL DIISOPROPYLPHOSPHORAMIDITE
Synonyms:
DIBENZYL DIISOPROPYLPHOSPHORAMIDITE;DIBENZYLOXY(DIISOPROPYLAMINO)PHOSPHINE;DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE;DIBENZYL-N,N-DIISOPROPYLPHOSPHOROAMIDITE;LABOTEST-BB LT00451623;DIBENZYL N,N-DIISOPROPYLPHOSPHORAMIDITE, TECHNICAL GRADE, 90%;bis(benzyloxy)(diisopropylamino)phosphine;β-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite
Categories:
Biochemical Engineering > Nucleoside Drugs

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Description

Clear Colourless Liquid

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Basic Attributes

Molecular Weight：

345.42

Exact Mass：

345.185760

EC Number：

2017-001-1

DSSTox ID：

DTXSID70148584

HScode：

29319090

Characteristics

PSA：

21.7

XLogP3：

4.8

Density：

1.028 g/mL at 25 °C(lit.)

Boiling Point：

130 °C0.55 mm Hg(lit.)

Flash Point：

158 °F

Refractive Index：

n 20/D 1.535(lit.)

Water Solubility：

Soluble in chloroform.

Storage Conditions：

Store at 0°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-37/39

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

bis(benzyloxy)(diisopropylamino)phosphine

DIBENZYL DIISOPROPYLPHOSPHORAMIDITE Use and Manufacturing

Methods of Manufacturing

Take compound 3-9, 42g (207.92mmo1) was placed in a 500mL round bottomed flask, was added 300mL of anhydrous tetrahydrofuran, 66mL (455.44mmol, 46g) of anhydrous triethylamine were dissolved with stirring. When the flask was placed in an ice-salt bath until the system temperature was lowered to 0 the right, under nitrogen was added dropwise over anhydrous benzyl alcohol 45mL (416.67mmol, 45g), was added dropwise maintaining temperature of the system is always near 0 , IH complete after the suspension was added dropwise to give a white solid containing the ice bath was removed to room temperature, stirring was continued at room temperature for 3h stirring was stopped to stand 10min, filtered off with suction, washed solid was tetrahydrofuran, the filtrate was collected, rotary evaporated to give tetrahydrofuran was no liquid column liquid chromatography to give an oil 54.0g, a yield of 75.3percent.

Uses

A versatile phosphitylating agent

Computed Properties

Molecular Weight:345.4
XLogP3:4.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:345.18576613
Monoisotopic Mass:345.18576613
Topological Polar Surface Area:21.7
Heavy Atom Count:24
Complexity:296
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzyl alcohol

Toluene

Tetrahydrofuran

Triethylamine

Ethyl acetate

Phosphorus trichloride

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Guide of DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
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DIBENZYL DIISOPROPYLPHOSPHORAMIDITE

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