Phosphorus trichloride

137.33300

137.33

231-749-3

M97C0A6S8U

0696

1809

DTXSID5029687

Clear colorless, fuming liquid|Colorless to yellow, fuming liquid.

2812104300

13.59000

2.92970

Phosphorus trichloride appears as a colorless or slightly yellow fuming liquid with a pungent and irritating odor resembling that of hydrochloric acid. Causes severe burns to skin, eyes and mucous membranes. Very toxic by inhalation, ingestion and skin absorption. Reacts with water to evolve hydrochloric acid, an irritating and corrosive gas apparent as white fumes. Used during electrodeposition of metal on rubber and for making pesticides, surfactants, gasoline additives, plasticizers, dyestuffs, textile finishing agents, germicides, medicinal products, and other chemicals.

1.574 g/cm³ @ Temp: 21 °C

-112 °C

76 °C

none

n20/D 1.5148(lit.)

Reacts

Store at RT.

23.32 psi ( 55 °C)

4.75 (vs air)

Noncombustible Liquid; however, a strong oxidizer that may ignite combustibles upon contact.

Reacts violently with water producing heat and decomposition products including hydrochloric acid and phosphorous acid, causing fire and explosion hazard.

Pungent

Decomposes rapidly in moist air|12.97 kPa (97.3 mm Hg)at 20 °C; 85.75 kPa (643 mm Hg) at 70 °C|Heat of formation: -319.7 kJ/mol; heat of evaporation: 31 kJ/mol; molar heat capacity: 120.9 J mol/K; rapidly hydrolyzed by water with evolution of heat to form phosphonic acid HP(O)(OH)2, and hydrochloric acid|Conversion factor: 1 ppm = 5.62 mg/cu m

Fumes in air. Reacts violently with water. Hydrolysis produces dense hydrogen chloride vapors. Phosphorus trichloride reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 0.14 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Acids, Strong Non-oxidizing

Water-Reactive

PHOSPHORUS TRICHLORIDE is a strong reducing agent that may ignite combustible organic materials upon contact. May generate flammable and potentially explosive gaseous hydrogen upon contact with many common metals (except nickel and lead). Reactions with water are violent and produce heat and flashes of fire. Gives intensely exothermic reactions with iodine monochloride [Mellor 2, Supp. 1:502. 1956]. Several laboratory explosions have been reported arising from mixtures with acetic acid, along with other acids, sulfuric acid and derivatives, carboxylic acids, etc. These have been ascribed to poor heat control allowing the formation of phosphine [J. Am. Chem. Soc. 60:488. 1938]. Ignites when mixed with hydroxylamine [Mellor 8:290. 1946-47]. Causes an explosion on contact with nitric acid [Comp. Rend. 28:86]. It is incompatible with many common oxidants such as: sodium peroxide, fluorine, chromyl chloride, iodine chloride, to name a few. Isopropanol can react with PCl3, forming toxic HCl gas. (Logsdon, John E., Richard A. Loke., Isopropyl Alcohol. Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 1996.)

Not flammable (USCG, 1999)

9.91 eV

Noncombustible Liquid; however, a strong oxidizer that may ignite combustibles upon contact.

The vapour is heavier than air.

Corrodes most common construction materials.

30.5 kJ/mol

Critical temperature: 285.5 °C

I

6.1

UN 1809

2

R14; R26/28; R35; R40; R48/20

S7/8-S26-S36/37/39-S45

TH3675000

C

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Dry. Well closed. Ventilation along the floor.

Stable, but light sensitive. Incompatible with water, many metals, fluorine, acids, variety of organic materials including acids, alcohols and reducing agents. Reaction with water is violent and yields toxic gas.

P260-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

H300 + H330-H314-H373

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Spillage should be handled only by an operator wearing full protective clothing and full-face mask/positive-pressure breathing apparatus. Absorbed spillage and residues should be buried in an approved landfill, away from water sources.

Reacts with water to form hydrochloric acid, which reacts with most metals to form flammable hydrogen gas.|Water, chemically-active metals such as sodium & potassium, aluminum, strong nitric acid, acetic acid, organic matter [Note: Hydrolyzes in water to form hydrochloric acid and phosphoric acid].|Use of free flame instead of a heating bath to distil acetyl chloride produced from acetic acid and phosphorus trichloride caused the residual phosphonic ('phosphorus') acid to decompose violently to give spontaneously flammable phosphine. Two later explosions in the same preparative system after reflux but before distillation from a water-bath may have been due to ingress of air into the cooling flask and ignition of traces of phosphine. During preparation of furoyl chloride, the excess trichloride was distilled off at atmospheric pressure, then vacuum was applied prior to intended distillation at 100 °C/100 mbar, and an explosion occurred shortly after. A similar incident occurred during conversion of propionic acid to the chloride. These incidents were attributed to thermal decomposition of the by-product phosphonic acid to give a phosphine-diphosphane mixture and leakage of air into the evacuated system to produce a spontaneously explosive mixture. Sulfinyl chloride is a safer chlorinating agent for carboxylic acids.|In the preparation of triphenylphosphine from chlorobenzene, phosphorus trichloride and sodium dispersed in toluene or xylene, the possibility of explosion is avoided by adding about 1 mol% of a lower alcohol, based on sodium usage.|For more Hazardous Reactivities and Incompatibilities (Complete) data for PHOSPHORUS TRICHLORIDE (25 total), please visit the HSDB record page.

European Chemicals Bureau; IUCLID Dataset, Phosphorus trichloride (7719-12-2) (2000 CD-ROM edition). INformation on usage patterns, toxicology, and environmental effects submitted by industry to the European Union. Available from the database query page: http://ecb.jrc.it/esis/esis.php as of November 03, 2006.

This material will react violently with water, producing heat and toxic and corrosive fumes. When heated to decomposition, it emits highly toxic fumes of chlorides and phosphorus oxides. It may ignite other combustible materials. Reacts violently with water. Reacts explosively with acetic acid, aluminum, chromyl chloride, diallylphosphite and allyl alcohol, dimethyl sulfoxide, fluorine, hydroxylamine, iodine monochloride, lead dioxide, nitric acid, nitrous acid, organic matter, potassium, and sodium. Avoid contact with water, steam, or acids. Hazardous polymerization may not occur. (EPA, 1998)|Not combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.|Corrosives, Reactive - 2nd degree

|Danger|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P280, P284, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P314, P320, P321, P330, P363, P403+P233, P405, and P501|H300+H330 (39.59%): Fatal if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]|Aggregated GHS information provided by 395 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P260, P264, P270, P271, P280, P284, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P314, P320, P321, P330, P363, P403+P233, P405, and P501|H260: In contact with water releases flammable gases which may ignite spontaneously [Danger Substances and mixtures which in contact with water, emit flammable gases]|P223, P231+P232, P260, P264, P270, P271, P280, P284, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P314, P320, P321, P330, P335+P334, P363, P370+P378, P402+P404, P403+P233, P405, and P501

Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1809 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 137 [Substances - Water-Reactive - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Use water spray to reduce vapors; do not put water directly on leak, spill area or inside container. Keep combustibles (wood, paper, oil, etc.) away from spilled material. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Wear special protective clothing and positive pressure self-contained breathing apparatus.|Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|For more Personal Protective Equipment (PPE) (Complete) data for PHOSPHORUS TRICHLORIDE (11 total), please visit the HSDB record page.|(See protection codes)

Reacts with water to form hydrochloric acid, which reacts with most metals to form flammable hydrogen gas.|... Phosphorus trichloride /is/ ... strongly corrosive and may set fire to combustible material /eg fibrous organic matter (wood, etc)/.|Not combustible, but if involved in a fire decomposes to produce hydrogen chloride, phosphoric acid, phosphine.|Not combustible. Many reactions may cause fire or explosion.

Reacts violently with water producing heat and decomposition products including hydrochloric acid and phosphorous acid, causing fire and explosion hazard.

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-third (1/3) mile radius.|If material on fire or involved in fire: Use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantites of water. Apply water from as far a distance as possible.|... Use water spray to knock down acid vapors.|NO hydrous agents. NO water ...

The vapor is heavier than air ... A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.|Severe health hazard. May be fatal if inhaled ... Corrosive ...|Reacts violently with fire extinguishing agents such as water ... Reacts violently with water producing heat and decomposition products including hydrochloric acid and phosphorous acid, causing fire and explosion hazard.

Environmental considerations: water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaCO3). Use mechanical dredges or lifts to remove immobilized masses of pollutant and precipitates. Adjust pH to neutral (pH=7).|Environmental considerations: air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.|Environmental considerations: land spill: Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3).|Releases may require isolation or evacuation. Use water spray to cool and disperse vapors and protect personnel.|For more Cleanup Methods (Complete) data for PHOSPHORUS TRICHLORIDE (6 total), please visit the HSDB record page.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|For more Preventive Measures (Complete) data for PHOSPHORUS TRICHLORIDE (9 total), please visit the HSDB record page.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.|Table of Water-Reactive Materials Which Produce Toxic Gases.|/GUIDE 137 SUBSTANCES - WATER-REACTIVE - CORROSIVE/ Fire or Explosion: EXCEPT FOR ACETIC ANHYDRIDE (UN1715), THAT IS FLAMMABLE, some of these materials may burn, but none ignite readily. May ignite combustibles (wood, paper, oil, clothing, etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Flammable/toxic gases may accumulate in confined areas (basement, tanks, hopper/tank cars, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. Substance may be transported in a molten form.|For more DOT Emergency Guidelines (Complete) data for PHOSPHORUS TRICHLORIDE (11 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Phosphorus trichloride is included on the dangerous goods list.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Phosphorus trichloride is included on the dangerous goods list.

... Irritating to eyes, skin, and respiratory system. ... Fumes from fires are irritating to respiratory passages, eyes, skin, and may contain phosphine, phosphoric acid, hydrogen chloride.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 0.5 ppm (3 mg/cu m).|Vacated 1989 OSHA PEL TWA 0.2 ppm (1.5 mg/cu m); STEL 0.5 ppm (3 mg/cu m) is still enforced in some states.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.2 ppm (1.5 mg/cu m).|Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 0.5 ppm (3 mg/cu m).

Evacuate danger area! Consult an expert! Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Dry. Well closed. Ventilation along the floor.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Exposure above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

NO contact with water.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 4 - Materials that, under emergency conditions, can be lethal.| 0 - Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand.| 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures.|W - No water: Materials that react violently or explosively with water.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).|Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Phosphorus trichloride is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000 lbs.

LD50 Rat oral 550 mg/kg|LC50 Rat inhalation 104 ppm/4 hr|LC50 Rat Inhalation 0.592 mg/L/4 hr|LC50 Rat inhalation 584 mg/cu m/4 hr|For more Non-Human Toxicity Values (Complete) data for PHOSPHORUS TRICHLORIDE (7 total), please visit the HSDB record page.

/AQUATIC SPECIES/ LC100s /of phosphorus trichloride are/ 57 mg/L/7 days /for/ sturgeon /and/ 65 mg/L/48 hr /for/ sturgeon (Acipenser), carp (Cyprinus carpio), perch (Percidae), Esox lucius (northern pike), and Leuciscus leuciscus (dace). NOEC /at/ pH 3.3 to 7.0 /and/ 22 to 24 °C /is/ 10 to 40 mg/L/30 days /for/ sturgeon, carp, perch, Esox lucius and Leuciscus leuciscus.|/AQUATIC SPECIES/ Aquatic toxicity range: 10 to 100 mg/L.

... People with pre-existing respiratory disease /should/ not work with respiratory irritants such as phosphorus trichloride ...

The estimated fatal dose of phosphorous trichloride is 1 g or ml ... /From table/

The substance can be absorbed into the body by inhalation or by ingestion.|Phosphorus trichloride /reacts/ with the water component of the tissues /it/ first contact. The resulting hydrogen chloride and phosphorus oxyacid ions, if absorbed, join the body pools of these ions. Phosphate, chloride, and hydrogen ions are easily excreted by the kidneys by normal physiological mechanisms.

Phosphorus trichloride /reacts/ with the water component of the tissues /it/ first contact. The resulting hydrogen chloride and phosphorus oxyacid ions, if absorbed, join the body pools of these ions. Phosphate, chloride, and hydrogen ions are easily excreted by the kidneys by normal physiological mechanisms.

PRODUCT MAY CONTAIN UNREACTED PHOSPHORUS.|TECHNICAL GRADE PHOSPHOROUS TRICHLORIDE HAS AN IMPURITY OF 1 PPM IRON.|The commercial product contains ca. 99% phosphorus trichloride, the main impurity being phosphoryl chloride.|Impurities that may be present in small amounts (<0.1%) include the arsenic and bromine analogues of phosphorus trichloride. The presence of these impurities and the hydrolysis products does not change the overall toxicity of technical phosphorus trichloride.

This material is highly toxic; it may cause death or permanent injury. Contact is highly irritating to the skin, eyes, and mucous membranes, and the material is an irritant through oral and inhalation exposure. (EPA, 1998)

Warning: Phosphorus trichloride is a corrosive agent. Contact with eyes may result in severe damage to the cornea, conjunctiva, and blood vessels. Caution is advised. Signs and Symptoms of Phosphorus Trichloride Exposure: Acute exposure to phosphorus trichloride may result in irritation and burning of the skin, eyes, and mucous membranes. Light- headedness, drowsiness, slurred speech, pupillary dilation, increased salivation, dysphagia (difficulty swallowing), abdominal pain, and spontaneous vomiting may occur. Stridor (high-pitched, noisy respirations), dyspnea (shortness of breath), and pulmonary edema are also common. Apathy and mental confusion may develop, with progression to coma and death. Emergency Life-Support Procedures: Acute exposure to phosphorus trichloride may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phosphorus trichloride. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to phosphorus trichloride. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 30 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Activated charcoal is of no value. 5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 6. Transport to a health care facility. (EPA, 1998)|(See procedures)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Chlorine and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Chlorine and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . If product was ingested, protect yourself from contact with vomitus as it may cause burns. /Phosphorus and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose stick or glucometer readings below 50 mg/dl) and administer 50% dextrose if necessary. Draw blood sample before administration ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phosphorus and related compounds/|For more Antidote and Emergency Treatment (Complete) data for PHOSPHORUS TRICHLORIDE (8 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ The signs of poisoning in 23 workers exposed to phosphorus trichloride at concentrations ranging from 1.8 to 27 ppm. Symptoms included burning eyes and throat, irritation of pharyngeal mucous membranes, and mild bronchitis; these changes occurred within 2 to 6 hours after exposure. Symptoms from subacute poisoning included irritation of the pharynx, coughing, dyspnea, and severe asthmatic bronchitis, which occurred 1 to 8 weeks after exposure. In workers who had at least 1 year exposure, emphysema was sometimes found. Both acute and subacute poisonings were frequently accompanied by fever and moderate leukocytosis and neutrophilia.|/SIGNS AND SYMPTOMS/ ... The corrosive effect /of phosphorus trichloride/ is complete destruction of skin or mucous membrane. /From table/|/SIGNS AND SYMPTOMS/ In a report of 17 persons exposed to phosphorus trichloride and its hydration products, those closest to the spill experienced burning eyes, lacrimation, nausea, vomiting, dyspnea, and cough. Pulmonary function tests showed decrements in vital capacity, maximal breathing capacity, and forced expiratory volume in direct correlation to the distance from the accident.|/SIGNS AND SYMPTOMS/ Phosphorus trichloride will cause severe burns upon direct dermal contact.|For more Human Toxicity Excerpts (Complete) data for PHOSPHORUS TRICHLORIDE (13 total), please visit the HSDB record page.

phosphorous trichloride

The substance can be absorbed into the body by inhalation and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, nose, throat; pulmonary edema; eye, skin burns

Sore throat. Cough. Burning sensation. Nausea. Vomiting. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Watering of the eyes. Severe deep burns. Loss of vision.

Eyes, skin, respiratory system

50% IS USED IN THE PRODUCTION OF PHOSPHORUS OXYCHLORIDE; 23% FOR PESTICIDES; 12% FOR PHOSPHITE AND PHOSPHATE ESTERS AND SALTS; 6% IN SURFACTANTS AND STABILIZERS; 9% IN MISC APPLICATIONS (1972).|CAPTIVE APPLICATIONS CONSUME OVER 40% OF PHOSPHORUS TRICHLORIDE.|END USE PATTERN-MERCHANT MARKET ONLY: PHOSPHITES, 37%; CHEMICAL INTERMEDIATES, 33%; ALKYL ARYL PHOSPHATES, 12%; QUATERNARIES, 10%; AGRICULTURAL, 5%; PHARMACEUTICALS, 4%; SURFACTANTS, 3% (1984-ESTIMATE).|CHEMICAL PROFILE: Phosphorus trichloride. Pesticide intermediate, 35%; phosphorus oxychloride, 25%; plastics additive (including flame retardants, plasticizers and antioxidants), 20%; phosphorous acid (mainly for water treatment chemicals), 10%; miscellaneous (including lube oil and paint additives and exports), 10%.|CHEMICAL PROFILE: Phosphorus trichloride. Demand: 1987: 102,000 tons; 1988: 104,000 tons; 1992 /projected/: 112,000 tons (Includes exports, which were about 2,000 tons in 1987; imports are negligible).

Grade; technical; 99.9%|TECHNICAL GRADE PHOSPHOROUS TRICHLORIDE HAS A MIN ASSAY OF 99.75%.

All other basic inorganic chemical manufacturing|Phosphorous trichloride: ACTIVE|Chemical Weapons Convention Schedule 3 B6 precursor.|Phosphorus trichloride is an effective chlorinating agent, which makes an ideal intermediate in preparing surfactants for mild, bar-type synthetic detergents. Phosphorus trichloride converts fatty acids into fatty acid chlorides.

NIOSH Method: Analyte: phosphorus trichloride; matrix: air; procedure: spectrophotometry.|NIOSH Method 6402: Analyte: Molybdenum blue; Matrix: Air; Procedure: Visible spectrophotometry; range: 0.03 to 0.5 mg phosphorus trichloride per sample; Estimated limit of detection: 0.003 mg phosphorus trichloride per sample; Precision: 0.06 at 0.03 to 0.14 mg phosphorus trichloride per sample.

Fire Hazards -> Corrosives, Reactive - 2nd degree