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(-)-Phellodendrine

(-)-Phellodendrine structure

CAS No:
6873-13-8
Formula:
C20H24NO4
Chemical Name:
(-)-Phellodendrine
Synonyms:
6H-Dibenzo[a,g]quinolizinium,5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-,(7S,13aS)-;13aα-Berbinium,2,11-dihydroxy-3,10-dimethoxy-7-methyl-;6H-Dibenzo[a,g]quinolizinium,5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-,(7S-cis)-;(7S,13aS)-5,8,13,13a-Tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-6H-dibenzo[a,g]quinolizinium;Phellodendrine;N-Methylcoreximine;(-)-Phellodendrine
Categories:
Biochemical Engineering > Chinese Herbs

Description

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect [1].

(-)-Phellodendrine Basic Attributes

Molecular Weight：

342.413

Exact Mass：

377.139374

DSSTox ID：

DTXSID50218855

Characteristics

PSA：

58.92000

XLogP3：

2.87390

Drug Information

MeSH Entry Terms：

OB-5 compound

Computed Properties

Molecular Weight:342.4
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:342.17053325
Monoisotopic Mass:342.17053325
Topological Polar Surface Area:58.9
Heavy Atom Count:25
Formal Charge:1
Complexity:488
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can quickly eliminate toxins from the body surface, have antibacterial effects, and promote the secretion of bile and pancreas.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	0.33g per tablet
Manufacturer	Jiangxi Wohua Jishun Pharmaceutical Co., Ltd.

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	Each capsule contains 0.36 grams (equivalent to 1 gram of the original medicinal material)

Huangbo Capsule
Ingredients	Berberine, palmatine, phellodendronine, β-sitosterol, dithyrol.
Indication	Not yet clear
Specifications	Each capsule is equivalent to 1g of original medicinal material
Manufacturer	Guangdong Jiulianshan Pharmaceutical Co., Ltd.

See More Related Drugs

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Guide of (-)-Phellodendrine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Drug Function and Efficacy
Related Drugs
Learn More Other Chemicals

(-)-Phellodendrine

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