N-[2-(2,4,6-Trichlorophenoxy)ethyl]-1-propanamine

An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.

The preparation method is to put 2-(2, 4, 6-trichlorophenoxy) ethyl chloride and a proper excess of n-propylamine into the amination kettle, stir and raise the temperature, react to a certain temperature, react for 8-10h, keep the temperature for 1～ 2h, after the reaction, discharge under reduced pressure, destroy the generated amine salt with alkali, recover n-propylamine, wash with water and extract with toluene, the oil layer is distilled under reduced pressure to obtain the finished product. It is also possible to use 2-(2, 4, 6-trichlorophenoxy) ethyl bromide as a raw material to mix with n-propylamine and heat to reflux for 8 hours. After the reaction, the n-propylamine is removed, acidified with hydrochloric acid, and filtered to obtain a white solid as a finished product.

N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]amine is an intermediate of the fungicide prochloraz.

Molecular Weight:282.6
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:281.014097
Monoisotopic Mass:281.014097
Topological Polar Surface Area:21.3
Heavy Atom Count:16
Complexity:182
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes