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4-Morpholinamine

4-Morpholinamine structure

CAS No:
4319-49-7
Formula:
C4H10N2O
Chemical Name:
4-Morpholinamine
Synonyms:
4-Morpholinamine;Morpholine,4-amino-;N-Aminomorpholine;4-Aminomorpholine;4-Morpholineamine;NSC 6825;(Morpholin-4-yl)amine
Categories:
Agrochemicals > Pesticide Intermediates

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Description

Clear colorless to faintly yellow liquid

4-Morpholinamine Basic Attributes

Molecular Weight：

102.14

Exact Mass：

102.14

EC Number：

224-347-4

UNII：

LG90NXJ1BP

NSC Number：

6825

DSSTox ID：

DTXSID60195769

HScode：

29349990

Characteristics

PSA：

38.5

XLogP3：

-1.1

Appearance：

Clear colorless to faintly yellow Liquid

Density：

1.1±0.1 g/cm3

Boiling Point：

166 °C

Flash Point：

137 °F

Refractive Index：

1.477

Water Solubility：

Micible with water.

Storage Conditions：

Store below +30°C.

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 1993 3/PG 3

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36-23-16

RTECS Number：

QD7300000

Marks：

Xn,F,Xi

Hazard note：

Harmful

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H226-H302-H312-H315-H319-H332-H335

GHS Classification：

|Danger|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 56 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-Morpholinamine Use and Manufacturing

Methods of Manufacturing

Derived from the cyclization of dichlorodiethyl ether and hydrazine hydrate. Add dichlorodiethyl ether, hydrazine hydrate and ethanol into the reaction tank, slowly heat up with stirring, and reflux for 2h. While maintaining reflux, sodium hydroxide was added in batches within 4 hours. Then cool to 10°C and filter, and discard the filter residue. The filtrate recovers ethanol under normal pressure until the recovered amount is 90% of the charged amount. The reaction solution was cooled to 40-50°C, and sodium hydroxide was added. Stir until the sodium hydroxide is dissolved and continue to stir for 30 min. Cool to 10-15°C, shake and filter, and discard the filter residue. The filtrate was extracted twice with toluene (the second extract was used in the next batch of reactions). After the toluene was recovered under reduced pressure, the 70-80°C (6.67kPa) fraction was collected. The content above 20% is a positive boiling substance, namely 4-aminomorpholine.

Uses

Pharmaceutical intermediates. Used for production?

Computed Properties

Molecular Weight:102.14
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:102.079312947
Monoisotopic Mass:102.079312947
Topological Polar Surface Area:38.5
Heavy Atom Count:7
Complexity:51.7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Morpholinamine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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N-Aminomorpholine

CAS No.: 4319-49-7

Content: 99.00%

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