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(+)-Bakuchiol

(+)-Bakuchiol structure

CAS No:
10309-37-2
Formula:
C18H24O
Chemical Name:
(+)-Bakuchiol
Synonyms:
Phenol,4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-;Phenol,4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)-,[S-(E)]-;Bakuchiol;Phenol,4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]-;4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol;Drupanol;(+)-Bakuchiol;(S)-(+)-Bakuchiol;UP 256;(S)-Bakuchiol;Bakutrol;Sytenol A;1408-17-9
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects.IC50 value:Target:in vitro: Bakuchiol reduced mitochondrial membrane potential (Psim) of cells in a concentration- and time-dependent manner, showing a more potent effect than that of resveratrol. S phase arrest, caspase 9/3 activaton, p53 and Bax up-regulation, as well as Bcl-2 down-regulation were observed in bakuchiol-treated A549 cells [1]. UGT2B7 was inhibited by the strongest inte

Bakuchiol is under investigation in clinical trial NCT03112863 (Comparison of the Cosmetic Effects of Bakuchiol and Retinol).

(+)-Bakuchiol Basic Attributes

Molecular Weight：

256.38

Exact Mass：

256.38

EC Number：

685-515-4

UNII：

OT12HJU3AR

NSC Number：

671195

HScode：

2907199090

Characteristics

PSA：

20.23000

XLogP3：

5.34410

Density：

0.963

Boiling Point：

145-147 °C @ Press: 0.7 Torr

Flash Point：

177℃

Refractive Index：

1.4500 (estimate)

Storage Conditions：

-20°C

Vapor Pressure：

1.1E-06mmHg at 25°C

Toxicity：

Oral-mouse LD50: 2560 mg/kg; intraperitoneal-mouse LD50; 94 mg/kg

Flammability characteristics：

Flammable; burning produces irritating fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

SL3785000

Storage features：

Ventilated, low temperature and dry

GHS Classification：

Not Classified

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH Entry Terms：

bakuchiol

(+)-Bakuchiol Use and Manufacturing

Uses

(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.

Use Classification：

Cosmetics -> Antimicrobial

Computed Properties

Molecular Weight:256.4
XLogP3:6.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:256.182715385
Monoisotopic Mass:256.182715385
Topological Polar Surface Area:20.2
Heavy Atom Count:19
Complexity:328
Defined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Pure Natural Extract Skin Care Psoralea Corylifolia Extract Bakuchiol

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4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL

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Bakuchiol 98%

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Content: 98%

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Guide of (+)-Bakuchiol

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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(+)-Bakuchiol

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