Uniconazole P

ChEBI: A (1E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol that has S configuration at the chiral centre. It is the enantiomer of (R)-uniconazole; the fungicide and p ant growth retardant uniconazole is the racemic mixture comprising (R)-uniconazole and uniconazole-P.

Preparation of α-(1, 2, 4-triazol-1-yl) pinacolone Dissolve 0.2 mol pinacolone in 80 mL glacial acetic acid, add 32 g of bromine dropwise, and continue the reaction for 0.5 h after dropping to obtain α-bromide Pinacolone, the yield is 67%. Then 13g of α-bromo pinacolone was added dropwise to the mixture of 5.3g 1, 2, 4-triazole and sodium ethoxide (1.9g sodium metal and 40mL absolute ethanol), reflux reaction, and after treatment, α -(1, 2, 4-triazol-1-yl) pinacolone, the yield is 76.7%. Preparation of triazolene: 0.05mol p-chlorobenzaldehyde, 0.05mol α-(1, 2, 4-triazol-1-yl) pinacolone, 50mL benzene and a certain amount of organic base are refluxed for 12h. Triazolinone was obtained after treatment with a yield of 70.3%. It is also reported that in the presence of light, heat or a catalyst, triazolone is isomerized, and the isomerization of triazolone can convert the Z configuration to the E configuration. Synthesis of Uniconazole Dissolve the above-mentioned product in 50mL methanol, add 0.33g sodium borohydride in batches, reflux for 1h, distill off methanol, add 1mol/L hydrochloric acid 25mL, produce white precipitate, filter, dry, and recrystallize from absolute ethanol , Get Uniconazole, the yield is 96%.

Broad spectrum azole plant growth regulator, gibberellin synthesis inhibitor. It has a strong growth inhibition effect on herbaceous or woody monocotyledonous or dicotyledonous crops. It has the functions of dwarfing plants, preventing lodging, and increasing the content of chlorophyll. This product has a small dosage and strong activity. It has a good inhibitory effect at a concentration of 10-30 mg/L, and will not deform the plant. It has a long shelf life and is safe for humans and animals. It can be used in rice, wheat, corn, peanut, soybean, cotton, fruit tree, flower and other crops. It can be sprayed with stems and leaves or soil treatment to increase the number of flowers. For example, for rice, barley, wheat sprayed with 10 ~ 100mg/L, for ornamental plants sprayed with 10 ~ 20mg/L. Uniconazole also has a high-efficiency, broad-spectrum, systemic bactericidal effect, and shows good bacteriostasis against rice blast, wheat root rot, corn spot disease, rice stem disease, wheat scab, and kidney bean anthracnose.