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N-Hydroxy-1-naphthalenecarboxamide

N-Hydroxy-1-naphthalenecarboxamide structure

CAS No:
6953-61-3
Formula:
C11H9NO2
Chemical Name:
N-Hydroxy-1-naphthalenecarboxamide
Synonyms:
1-Naphthalenecarboxamide,N-hydroxy-;1-Naphthohydroxamic acid;N-Hydroxy-1-naphthalenecarboxamide;α-Naphthohydroxamic acid;NSC 57457
Categories:
Chemical Reagents > Organic Reagents

Description

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].

N-Hydroxy-1-naphthalenecarboxamide Basic Attributes

Molecular Weight：

187.19

Exact Mass：

187.19

NSC Number：

57457

DSSTox ID：

DTXSID30219789

HScode：

2924299090

Characteristics

PSA：

49.3

XLogP3：

1.49

Appearance：

white to tan

Density：

1.3±0.1 g/cm3

Melting Point：

176-178 °C

Refractive Index：

1.678

Water Solubility：

DMSO: ≥5mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

QJ1894500

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Computed Properties

Molecular Weight:187.19
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:187.063328530
Monoisotopic Mass:187.063328530
Topological Polar Surface Area:49.3
Heavy Atom Count:14
Complexity:217
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of N-Hydroxy-1-naphthalenecarboxamide

Description
Basic Attributes
Characteristics
Safety Information
Computed Properties
Latest News
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N-Hydroxy-1-naphthalenecarboxamide

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