2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol
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![2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220805/d35688a4dcbd48ccaf6e9e8ba6dc5308.png "2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol")
2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol
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CAS No:
223137-87-9
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Formula:
C17H16O2
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Chemical Name:
2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol
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Synonyms:
2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol;2,2',3,3'-Tetrahydro-1,1'-spirobi[indene]-7,7'-diol;2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol, 99%e.e.;SPINOL
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CAS No:
2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol Basic Attributes
252.31
252.115036
2906299090
2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol Use and Manufacturing
To the above white powder was added8. 00 gTetrabutyl bromide Press, Then add 300.00 mL of 48percent hydrogen bromide solution, As for the 105 ° C oil bath, Reaction overnightAfter cooling, add 500. 00 mL of deionized water, Then add 500. 00 mL of dichloromethane, After stirring for 30 minutes, The organic phase is separated, And then to 500. 00 mL deionized water, 500. 00 mL saturated aqueous sodium bicarbonate solution and 500. 00 mL saturated brine to wash the organic phase, Concentrated solvent to be applied, To obtain a pink powder, The powder was recrystallized from petroleum ether / ethyl acetate (8: 2, ν / ν)57 g of a white powder was obtained, The total yield was 45percent. Using a 48percent aqueous solution of HBr in which the demethylating agent is readily accessible, is easy to store, and the reaction is mild without having to be particularly low orParticularly high temperatures, and yields higher than other methods; the method of purifying intermediates and final products is recrystallization, No longer use the higher cost, solid waste more column chromatography separation and purification methods, and the amount of solvent used significantly reduced.
Computed Properties
Molecular Weight:252.31
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:252.115029749
Monoisotopic Mass:252.115029749
Topological Polar Surface Area:40.5
Heavy Atom Count:19
Complexity:319
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol
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