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Amentoflavone

Amentoflavone structure

CAS No:
1617-53-4
Formula:
C30H18O10
Chemical Name:
Amentoflavone
Synonyms:
4H-1-Benzopyran-4-one,8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-;3′′′,8-Biflavone,4′,4′′′,5,5′′,7,7′′-hexahydroxy-;Ginkgetin,didemethyl-;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Amentoflavone;Tridemethylsciadopitysin;I3′,II8-Biapigenin;Amenthoflavone;NSC 295677;79596-89-7
Categories:
Cosmetic Ingredient > Bleaching Agent

Description

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.IC50 value:Target:In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass [2]. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concent

Solid

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as a cathepsin B inhibitor, an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor and a plant metabolite. It is a biflavonoid, a hydroxyflavone and a ring assembly.

Amentoflavone Basic Attributes

Molecular Weight：

538.46

Exact Mass：

538.46

UNII：

9I1VC79L77

NSC Number：

295677

DSSTox ID：

DTXSID20167225

HScode：

29329990

Characteristics

PSA：

174

XLogP3：

Appearance：

Odourless Whitish Solid

Density：

1.656±0.06 g/cm3(Predicted)

Melting Point：

245-250 °C (decomp)

Boiling Point：

910.5°C at 760 mmHg

Flash Point：

308.5±27.8 °C

Refractive Index：

1.793

Water Solubility：

0.03344 mg/L @ 25 °C (est)

Storage Conditions：

2-8°C

Vapor Pressure：

2.79E-35mmHg at 25°C

Collision Cross Section：

230.16 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|217.23 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|216.5 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

Drug Information

MeSH：

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP3A. (See all compounds classified as Cytochrome P-450 CYP3A Inhibitors.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C9. (See all compounds classified as Cytochrome P-450 CYP2C9 Inhibitors.)

MeSH Entry Terms：

amentoflavone

Amentoflavone Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Biflavonoids and polyflavonoids [PK1204]

Computed Properties

Molecular Weight:538.5
XLogP3:5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:538.08999677
Monoisotopic Mass:538.08999677
Topological Polar Surface Area:174
Heavy Atom Count:40
Complexity:1050
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 1617-53-4

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Content: 98%

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Amentoflavone 1617-53-4

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Guide of Amentoflavone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Amentoflavone

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