Amentoflavone
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Amentoflavone
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CAS No:
1617-53-4
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Formula:
C30H18O10
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Chemical Name:
Amentoflavone
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Synonyms:
4H-1-Benzopyran-4-one,8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-;3′′′,8-Biflavone,4′,4′′′,5,5′′,7,7′′-hexahydroxy-;Ginkgetin,didemethyl-;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Amentoflavone;Tridemethylsciadopitysin;I3′,II8-Biapigenin;Amenthoflavone;NSC 295677;79596-89-7
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CAS No:
Description
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.IC50 value:Target:In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass [2]. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concent
Solid
Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as a cathepsin B inhibitor, an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor and a plant metabolite. It is a biflavonoid, a hydroxyflavone and a ring assembly.
Characteristics
174
5
Odourless Whitish Solid
1.656±0.06 g/cm3(Predicted)
245-250 °C (decomp)
910.5°C at 760 mmHg
308.5±27.8 °C
1.793
0.03344 mg/L @ 25 °C (est)
2-8°C
2.79E-35mmHg at 25°C
230.16 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|217.23 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|216.5 Ų [M-H]-
Drug Information
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP3A. (See all compounds classified as Cytochrome P-450 CYP3A Inhibitors.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C9. (See all compounds classified as Cytochrome P-450 CYP2C9 Inhibitors.)
amentoflavone
Amentoflavone Use and Manufacturing
Polyketides [PK] -> Flavonoids [PK12] -> Biflavonoids and polyflavonoids [PK1204]
Computed Properties
Molecular Weight:538.5
XLogP3:5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:538.08999677
Monoisotopic Mass:538.08999677
Topological Polar Surface Area:174
Heavy Atom Count:40
Complexity:1050
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Amentoflavone
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![China]()
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Business licensedTrader Supplier of Apigenin,PQQ,NMNHInquiryUnit Price: $5.1-6.12 /G FOBCAS No.: 1617-53-4Grade: Chemical GradeContent: 99% -
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