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Hydroxytyrosol

Hydroxytyrosol structure

CAS No:
10597-60-1
Formula:
C8H10O3
Chemical Name:
Hydroxytyrosol
Synonyms:
1,2-Benzenediol,4-(2-hydroxyethyl)-;Phenethyl alcohol,3,4-dihydroxy-;4-(2-Hydroxyethyl)-1,2-benzenediol;β-(3,4-Dihydroxyphenyl)ethanol;3,4-Dihydroxyphenylethanol;Ba 2774;3,4-Dihydroxyphenethyl alcohol;β-(3,4-Dihydroxyphenyl)ethyl alcohol;3-Hydroxytyrosol;3,4-Dihydroxy-β-phenethyl alcohol;Homoprotocatechuyl alcohol;1-(2-Hydroxyethyl)-3,4-dihydroxybenzene;2-(3,4-Dihydroxyphenyl)ethanol;3,4-Dihydroxyphenylethyl alcohol;2-(3,4-Dihydroxyphenyl)ethyl alcohol;Hydroxytyrosol;3,4-DHPEA;3,4-Dihydroxybenzeneethanol
Categories:
Cosmetic Ingredient > Bleaching Agent

Description

Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].

Solid

Hydroxytyrosol is a member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a member of catechols and a primary alcohol. It derives from a 2-(4-hydroxyphenyl)ethanol.|Hydroxytyrosol has been used in trials studying the prevention of Breast Cancer.|Hydroxytyrosol is a phenolic phytochemical naturally occurring in extra virgin olive oil, with potential antioxidant, anti-inflammatory and cancer preventive activities. Although the mechanisms of action through which hydroxytyrosol exerts its effects have yet to be fully determined, this agent affects the expression of various components of the inflammatory response, possibly through the modulation of the nuclear factor-kappa B (NF-kB) pathway. The effects include the modulation of pro-inflammatory cytokines, such as the inhibition of interleukin-1alpha (IL-1a), IL-1beta, IL-6, IL-12, and tumor necrosis factor-alpha (TNF-a); increased secretion of the anti-inflammatory cytokine IL-10; inhibition of the production of certain chemokines, such as C-X-C motif chemokine ligand 10 (CXCL10/IP-10), C-C motif chemokine ligand 2 (CCL2/MCP-1), and macrophage inflammatory protein-1beta (CCL4/MIP-1b); and inhibition of the expression of the enzymes inducible nitric oxide synthase (iNOS/NOS2) and prostaglandin E2 synthase (PGES), which prevent the production of nitric oxide (NO) and prostaglandin E (PGE2), respectively. In addition, hydroxytyrosol is able to regulate the expression of other genes involved in the regulation of tumor cell proliferation, such as extracellular signal-regulated and cyclin-dependent kinases. Also, hydroxytyrosol scavenges free radicals and prevents oxidative DNA damage. This induces apoptosis and inhibits proliferation in susceptible cancer cells.

Hydroxytyrosol Basic Attributes

Molecular Weight：

154.16300

Exact Mass：

154.16

UNII：

QEU0NE4O90

DSSTox ID：

DTXSID70147451

NCI Thesaurus Code：

C63690

HScode：

2907299090

Characteristics

PSA：

60.69000

XLogP3：

-0.7

Appearance：

Solid

Density：

1.321 g/cm3

Boiling Point：

355.4ºC at 760 mmHg

Flash Point：

182.6ºC

Refractive Index：

1.622

Water Solubility：

2.716e+005 mg/L @ 25 °C (est)

Storage Conditions：

Refrigerator

Vapor Pressure：

1.15E-05mmHg at 25°C

Collision Cross Section：

130.6 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (93.33%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

MeSH Entry Terms：

2-(3,4-dihydroxyphenyl)ethanol

Hydroxytyrosol Use and Manufacturing

Tyrosol (T947800) metabolite.

Computed Properties

Molecular Weight:154.16
XLogP3:-0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:154.062994177
Monoisotopic Mass:154.062994177
Topological Polar Surface Area:60.7
Heavy Atom Count:11
Complexity:116
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Potent antioxidant,清除自由基, reduces oxidative stress and delays cellular aging

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Manufacturer	DNA Labs, Inc.

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