 Home > Encyclopedia > Tolmetin sodium

Tolmetin sodium

Tolmetin sodium structure

CAS No:
35711-34-3
Formula:
C15H15NO3.Na
Chemical Name:
Tolmetin sodium
Synonyms:
1H-Pyrrole-2-acetic acid,1-methyl-5-(4-methylbenzoyl)-,sodium salt (1:1);1H-Pyrrole-2-acetic acid,1-methyl-5-(4-methylbenzoyl)-,sodium salt;Sodium tolmetin;Tolectin;Tolmetin sodium;Sodium 1-methyl-5-p-toluoylpyrrole-2-acetate;Tolmetin sodium salt
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Tolmetin sodium is an organic sodium salt that is the monosodium salt of tolmetin. Used in the form of its dihydrate as a nonselective nonsteroidal anti-inflammatory drug. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a non-steroidal anti-inflammatory drug. It contains a tolmetin(1-).|A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.

Tolmetin sodium Basic Attributes

Molecular Weight：

279.27

Exact Mass：

279.08700

EC Number：

252-687-3

UNII：

WL259637KX

DSSTox ID：

DTXSID2091546

HScode：

2933990090

Characteristics

PSA：

62.1

XLogP3：

0.85690

Density：

1.18g/cm3

Melting Point：

155-157ºC (DECOMPOSES)

Boiling Point：

483.2ºC at 760 mmHg

Flash Point：

246ºC

Collision Cross Section：

158.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Precautionary statement(s)：

P264, P270, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|P264, P270, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

MeSH Entry Terms：

Anhydrous Tolmetin Sodium

Tolmetin sodium Use and Manufacturing

Uses

Antipyretic analgesic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:279.27
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:279.08713759
Monoisotopic Mass:279.08713759
Topological Polar Surface Area:62.1
Heavy Atom Count:20
Complexity:353
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

By inhibiting cyclooxygenase, it blocks the synthesis of prostaglandins from arachidonic acid, thereby exerting analgesic, anti-inflammatory and antipyretic effects

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Tolmetin Sodium Capsules
Ingredients	The main ingredient is tolmetin sodium, the chemical name is tolmetin sodium (dihydrate); 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl] acetate sodium (dihydrate), molecular formula: C15H14NNaO3.2(H2O), molecular weight: 315.30
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	0.2 g

Tolmetin Sodium Capsules
Ingredients	The main ingredient is Tolmetin sodium. The chemical name is Tolmetin sodium (dihydrate); 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl] acetate sodium (dihydrate). Molecular formula: C15H14NNaO3.2 (H2O). Molecular weight: 315.30
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	0.2g*18s

Tolmetin Sodium Capsules
Ingredients	The main ingredient is tolmetin sodium; the chemical name is tolmetin sodium (dihydrate); 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl] acetate sodium (dihydrate); molecular formula: C15H14NNaO3.2(H2O); molecular weight: 315.30
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	0.2g
Manufacturer	China Resources 39 (Beijing) Pharmaceutical Co., Ltd.

Registered Holders

MATRIX PHARMACORP PRIVATE LTD

United States
Active
Orion Corp Ltd

Mauritius
Inactive
COSMA S.P.A.

Brazil
Inactive

See More Registered Holders