 Home > Encyclopedia > Epirizole

Epirizole

Epirizole structure

CAS No:
18694-40-1
Formula:
C11H14N4O2
Chemical Name:
Epirizole
Synonyms:
Pyrimidine,4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-;Pyrimidine,4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl-;4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine;1-(4-Methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;DA 398;Mepirizole;1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine;2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine;2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine;Mebron;Epirizole
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Epirizole is an aromatic ether.|Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain.|4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.

Epirizole Basic Attributes

Molecular Weight：

234.25

Exact Mass：

234.25

EC Number：

242-507-1

UNII：

3B46O2FH8I

DSSTox ID：

DTXSID4045422

HScode：

2933990090

Characteristics

PSA：

62.1

XLogP3：

1.29630

Appearance：

Yellow power

Density：

1.1972 (rough estimate)

Melting Point：

90-92 °C

Boiling Point：

376.57°C (rough estimate)

Flash Point：

222.3ºC

Refractive Index：

1.6000 (estimate)

Water Solubility：

>35.1 [ug/mL]

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

LD50 orally in mice: 820 mg/kg (Ogura)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

RTECS Number：

UV9290000

Marks：

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H312-H315-H319-H332-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

Epirizole

Epirizole Use and Manufacturing

Analgesic; anti-inflammatory.

Computed Properties

Molecular Weight:234.25
XLogP3:1.3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:234.11167570
Monoisotopic Mass:234.11167570
Topological Polar Surface Area:62.1
Heavy Atom Count:17
Complexity:254
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes