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Floctafenine

Floctafenine structure

CAS No:
23779-99-9
Formula:
C20H17F3N2O4
Chemical Name:
Floctafenine
Synonyms:
Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-,2,3-dihydroxypropyl ester;Anthranilic acid,N-[8-(trifluoromethyl)-4-quinolyl]-,2,3-dihydroxypropyl ester;Glycerol,1-[N-[8-(trifluoromethyl)-4-quinolyl]anthranilate];Floctafenin;Floctafenine;RU 15750;Idarac;R 4318;Idalon;R 4138;Diralgan;Novodolan;2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Floctafenine is an organic molecular entity.|Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.

Floctafenine Basic Attributes

Molecular Weight：

406.36

Exact Mass：

406.36

EC Number：

245-881-4

DSSTox ID：

DTXSID8057695

ATC Code：

N - Nervous system

HScode：

2933499090

Characteristics

PSA：

91.7

XLogP3：

3.7

Density：

1.3473 (estimate)

Melting Point：

179.5 °C

Boiling Point：

592.1ºC at 760 mmHg

Flash Point：

311.9ºC

Refractive Index：

1.63

Vapor Pressure：

7.26E-15mmHg at 25°C

Toxicity：

LD50 in male mice, rats (mg/kg): 3400, 960 orally; 180, 160 i.v. (Glomot)

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

Duralgin

Floctafenine Use and Manufacturing

Uses

Floctafenine is an nonsteroidal antiinflammatory drug (NSAID) used in inflammatory disorders.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:406.4
XLogP3:3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:406.11404151
Monoisotopic Mass:406.11404151
Topological Polar Surface Area:91.7
Heavy Atom Count:29
Complexity:548
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes