4-Chloro-2-fluoropyridine
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4-Chloro-2-fluoropyridine
structure -
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CAS No:
34941-92-9
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Formula:
C5H3ClFN
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Chemical Name:
4-Chloro-2-fluoropyridine
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Synonyms:
Pyridine,4-chloro-2-fluoro-;4-Chloro-2-fluoropyridine
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CAS No:
4-Chloro-2-fluoropyridine Use and Manufacturing
To a solution of compound 4-chloropyridin-2-amine (500 mg, 3.90 mmol) in HF-pyridine (2.5 mL) was added sodium nitrite (296 mg, 4.29 mmol) in portions at 0 C. Reaction mixture was stirred at 10 C for 1 h. Reaction mixture diluted with water and extracted with DCM (25 mL X 2). The combined organic layer was dried over sodium sulphate and concentrated at reduced pressure to get crude title compound as brown liquid (350 mg, 68.46 %) Rf = 0.7(100 % n-Hexane); 1 H NMR (300 MHz, DMSO-d6) d 8.27 (dd, J = 5.3, 0.8 Hz, 1 H), 7.59 - 7.42 (m, 2H) ; LC-MS m/z 132.05 [M+H]+, retention time = 1 .40 min (Method A); HPLC: 90.08 %, retention time = 5.1 1 min (Method F)[00281 ] To a cooled solution of 4.2 g (32 mmol) of 1) Under a nitrogen atmosphere, 0.30 g (2.30 mmol) of General procedure: To a solution of
Computed Properties
Molecular Weight:131.53
XLogP3:1.9
Hydrogen Bond Acceptor Count:2
Exact Mass:130.9938050
Monoisotopic Mass:130.9938050
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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