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2,4-Difluoropyridine

2,4-Difluoropyridine structure

CAS No:
34941-90-7
Formula:
C5H3F2N
Chemical Name:
2,4-Difluoropyridine
Synonyms:
Pyridine,2,4-difluoro-;2,4-Difluoropyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

colorless liquid

2,4-Difluoropyridine Basic Attributes

Molecular Weight：

115.08

Exact Mass：

115.08

DSSTox ID：

DTXSID00376499

HScode：

2933399090

Characteristics

PSA：

12.9

XLogP3：

1.4

Appearance：

Colorless liquid

Density：

1.3±0.1 g/cm3

Boiling Point：

104-106 °C

Flash Point：

27.8±21.8 °C

Refractive Index：

1.447

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

1993

hazard class code：

Marks：

Xi,F

Precautionary statement(s)：

P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501

Hazard Statements：

H226

GHS Classification：

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 9 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,4-Difluoropyridine Use and Manufacturing

A solution of 2, 4-difluoro pyridine (5 g, 43.4 mmol) in THF (120 ml.) was added dropwise to a stirring solution of lithium diisopropylamide (2M in THF/heptane/ethylbenzene, 26.1 ml_, 52.1 mmol) at -78 C. After stirring for 1 h, the reaction was transferred to a stirring solution of methyl chloroformate (5.05 ml_, 65.2 mmol) in THF (120 ml.) at -78 C via cannula. The reaction mixture was allowed to warm to RT over 30 min. The reaction was quenched slowly with water (100 ml.) and was extracted with EtOAc (3x100ml_). The organics were combined, dried with Na2S04, filtered, and volatiles were removed in vacuo. The product was purified by silica gel chromatography (EtOAc / heptane) to give the title compound. LCMS: Rt = 0.94 min, m/z 174.1 (M+H) (LCMS method 1 ).

Computed Properties

Molecular Weight:115.08
XLogP3:1.4
Hydrogen Bond Acceptor Count:3
Exact Mass:115.02335542
Monoisotopic Mass:115.02335542
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2,4-Difluoropyridine

CAS No.: 34941-90-7

Content: 99.00%

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Shaanxi Kaierkai Pharmaceutical Technolo Contact Supplier

CN
3 YRS

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2,4-DIFLUORO-PYRIDINE KEK

CAS No.: 34941-90-7

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