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N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide structure

CAS No:
141430-65-1
Formula:
C18H17N3O4S
Chemical Name:
N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide
Synonyms:
Benzenesulfonamide,N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-;N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide;E 7010;E 7010 (pharmaceutical);N-[2-[(4-Hydroxyphenyl)amino]-3-pyridyl]-4-methoxybenzenesulfonamide;ABT 51;ABT 751;857447-92-8
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.IC50 Value: 1.5 μM(neuroblastoma); 3.4 μM(non-neuroblastoma)Target: Microtubule/Tubulinin vitro: ABT-751 shows the selective cytotoxicity with IC50 of 0.6–2.6 μM in neuroblastoma and 0.7–4.6 μM in other solid tumor cell lines. Furthermore, ABT-751 also exhibits a selective effect on dynamic microtubules

N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.|ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.|Colchicine-Site Binding Agent ABT-751 is an orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04)

N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide Basic Attributes

Molecular Weight：

371.411

Exact Mass：

371.41

UNII：

WDT5V5OB9F

NSC Number：

742134

NCI Thesaurus Code：

C2679

Characteristics

PSA：

109

XLogP3：

2.8

Density：

1.427

Boiling Point：

551.0±60.0 °C(Predicted)

Flash Point：

287.0±32.9 °C

Refractive Index：

1.677

Vapor Pressure：

9.51E-13mmHg at 25°C

Safety Information

RTECS Number：

DB2734000

Precautionary statement(s)：

P201, P202, P260, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P314, P330, P337+P313, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P314, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 80 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

E 7010

Computed Properties

Molecular Weight:371.4
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:371.09397721
Monoisotopic Mass:371.09397721
Topological Polar Surface Area:109
Heavy Atom Count:26
Complexity:523
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Anqing Rongchuang Biotechnology Co., Ltd Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of SR17018

ABT-751;E7010

Unit Price: $460.51 /G FOB

CAS No.: 141430-65-1

Content: 98%

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Guide of N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Recommended Suppliers
Latest News
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N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

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