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2,6-Dichloro-4-pyridinol

2,6-Dichloro-4-pyridinol structure

CAS No:
17228-74-9
Formula:
C5H3Cl2NO
Chemical Name:
2,6-Dichloro-4-pyridinol
Synonyms:
4-Pyridinol,2,6-dichloro-;2,6-Dichloro-4-pyridinol;2,6-Dichloro-4-hydroxypyridine;2,6-Dichloro-1H-pyridin-4-one
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2,6-Dichloro-4-pyridinol Basic Attributes

Molecular Weight：

164

Exact Mass：

163.99

HScode：

2933399090

Characteristics

PSA：

29.1

XLogP3：

1.8

Density：

1.561±0.06 g/cm3(Predicted)

Melting Point：

196 °C

Boiling Point：

424.3±40.0 °C(Predicted)

Flash Point：

210.4±27.3 °C

Refractive Index：

1.602

Vapor Pressure：

0.0326mmHg at 25°C

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

2,6-Dichloro-4-pyridinol Use and Manufacturing

(900 mg, 5.49 mmol), ethyl difluoroacetate (2.23) g, 11.0mmol)A mixture of potassium carbonate (1.52 g, 11.0 mmol) in N, N-dimethylformamide (20 mL) was stirred at 40 C for 5 hours. The reaction solution was cooled to room temperature and diluted with water (10 mL).Extraction with ethyl acetate (20 mL X 2 ), The organic phase was dried over anhydrous sodium sulfate and filtered.The filtrate was concentrated under reduced pressure and the residue was purified eluting with flash column ( petroleum ether / ethyl acetate = 10/1)Purification afforded 2, 6-dichloro-4-(difluoromethoxy)pyridine (1.0 g, 85%) as a colourless oil.Step 1: Synthesis of 2, 6-dichloro-4-(difluoromethoxy)pyridine (0385) 720 mg (5.21 mmol) of potassium carbonate were added at room temperature to a mixed solution of 600 mg (3.66 mmol) of

Computed Properties

Molecular Weight:163.99
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:162.9591691
Monoisotopic Mass:162.9591691
Topological Polar Surface Area:29.1
Heavy Atom Count:9
Complexity:187
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes