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2-Chloro-5-hydroxypyridine

2-Chloro-5-hydroxypyridine structure

CAS No:
41288-96-4
Formula:
C5H4ClNO
Chemical Name:
2-Chloro-5-hydroxypyridine
Synonyms:
6-CHLOROPYRIDIN-3-OL;6-Chloro-3-pyridinol;3-PYRIDINOL, 6-CHLORO-;2-CHLORO-5-HYDROXYPYRIDINE;2-CHLORO-5-PYRIDINOL;2-Chloro-5-Pyridol;2-Chloropyridin-5-ol;3-Pyridinol,6-chloro-(9CI)
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Light yellow Cryst

2-Chloro-5-hydroxypyridine Basic Attributes

Molecular Weight：

129.54

Exact Mass：

128.998138

EC Number：

1533716-785-6

DSSTox ID：

DTXSID50356120

HScode：

2933399090

Characteristics

PSA：

33.1

XLogP3：

1.4

Appearance：

Light yellow cryst

Density：

1.4±0.1 g/cm3

Melting Point：

155-158°C

Boiling Point：

351.9°C at 760 mmHg

Flash Point：

166.6±22.3 °C

Refractive Index：

1.584

Safety Information

Packing level：

III

Hazard category：

IRRITANT

hazard class code：

36/37/38-22

safety instructions：

26-36/37/39-36-37

Marks：

T,Xi,Xn

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 10 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-chloro-5-hydroxypyridine

2-Chloro-5-hydroxypyridine Use and Manufacturing

2-Chloro-5-acetoxypyridine (21.66 g, 126 mmol) was dissolved in 300 mL of methanol and K2CO3(8.70 g, 63 mmol) was added. The reaction was stirred at room temperature for approx. 2 h, then concentrated in vacuo. The residue was diluted with diethyl ether and water, and the aqueous layer was adjusted to neutral pH by the addition of 1N aqueous HCl. Following extraction with diethyl ether, the organics were combined, washed with a solution of saturated aqueous NaCl, dried with MgSO4, and concentrated in vacuo. The resulting yellow solid (15.58 g, 96percent) was used without further purification.11b. 3) 2-Chloro-5-hydroxypyridine; Potassium carbonate (400 mg) was added to a solution of the 5-acetoxy-2-chloropyridine (10 g) in methanol (200 ml), and the mixture was stirred at room temperature for 20 hours. The reaction solvent was evaporated under reduced pressure, and the residue was purified by chromatography on silica gel (ethyl acetate) to give 2-chloro-5-hydroxypyridine (6.86 g, 91percent) as a solid. To a solution of acetic acid 6-chloro-pyridin-3-yl ester (1.67 g, 9.8 MMOL) in methanol (10 mL) was added potassium carbonate (676 mg, 4.9 MMOL), and the resulting reaction stirred at ambient temperature for 2 hours. The reaction was concentrated to an oily solid which was partitioned between water and diethyl ether. The water layer was neutralized with 3N HCI (3.7 mL), and extracted with diethyl ether (1X). The organics were combined, washed with brine, dried over sodium sulfate, and concentrated in vacuo to give the above named compound as a tan solid (1.04 g, 82percent).

Computed Properties

Molecular Weight:129.54
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:128.9981414
Monoisotopic Mass:128.9981414
Topological Polar Surface Area:33.1
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Chloro-5-hydroxypyridine

Shandong Ranhang Biotechnology Co., Ltd. Contact Supplier

CN
3 YRS

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Trader Supplier of chemical

2-Chloro-5-hydroxypyridine CAS: 41288-96-4 C5H4ClNO with stock

CAS No.: 41288-96-4

Content: 99.5%

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Tianjin Jinshu Technology Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Distributor Supplier of peptone

2-Chloro-5-Hydroxypyridine factory direct white raw powder high quality

CAS No.: 41288-96-4

Grade: Pharmaceutical Grade

Content: 99%

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Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

2-Chloro-5-hydroxypyridine

CAS No.: 41288-96-4

Grade: pharmaceutical grade

Content: 98%

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Guide of 2-Chloro-5-hydroxypyridine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-Chloro-5-hydroxypyridine

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