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4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol structure

CAS No:
215303-72-3
Formula:
C27H24FN3O
Chemical Name:
4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
Synonyms:
3-Butyn-1-ol,4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-;4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol;RWJ 67657;4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole;JNJ 3026582
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

RWJ 67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ 67657 displays no activity at p38γ and p38δ, and exhibits cardio protective. Anti-inflammatory and anti-tumor activity[1].

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Basic Attributes

Molecular Weight：

425

Exact Mass：

425.50

DSSTox ID：

DTXSID40175867

Characteristics

PSA：

50.9

XLogP3：

5.18

Density：

1.1±0.1 g/cm3

Melting Point：

124 °C

Boiling Point：

611.8±65.0 °C at 760 mmHg

Flash Point：

323.8±34.3 °C

Refractive Index：

1.599

Storage Conditions：

Store at RT

Vapor Pressure：

8.01E-16mmHg at 25°C

Drug Information

MeSH Entry Terms：

4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-3-butyn-1-ol

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Use and Manufacturing

RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,

Computed Properties

Molecular Weight:425.5
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:425.19034056
Monoisotopic Mass:425.19034056
Topological Polar Surface Area:50.9
Heavy Atom Count:32
Complexity:611
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Latest News
Learn More Other Chemicals

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

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