5-Fluoro-3-nitro-2(1H)-pyridinone
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5-Fluoro-3-nitro-2(1H)-pyridinone
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CAS No:
136888-20-5
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Formula:
C5H3FN2O3
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Chemical Name:
5-Fluoro-3-nitro-2(1H)-pyridinone
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Synonyms:
2(1H)-Pyridinone,5-fluoro-3-nitro-;5-Fluoro-3-nitro-2(1H)-pyridinone;5-Fluoro-2-hydroxy-3-nitropyridine;5-Fluoro-3-nitropyridin-2-ol
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CAS No:
Characteristics
74.9
0.1
Solid
1.55±0.1 g/cm3(Predicted)
249.1±40.0 °C(Predicted)
144.1±26.5 °C
1.590
Slightly soluble in water.
Room temperature.
0mmHg at 25°C
Safety Information
26-36/37
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
5-Fluoro-3-nitro-2(1H)-pyridinone Use and Manufacturing
a)5-Fluoro-2-methoxypyridin-3 -amine a) 5-Fluoro-3-nitropyridin-2-olA mixture of concentrated sulphuric acid (1 mL) and fuming nitric acid (1 mL) was added dropwise to a stirred, cooled (ice-bath) mixture of 5-fluoropyridin-2-ol (1 .20 g, 10.6 mmol) and concentrated sulphuric acid (2.7 mL). The mixture was warmed to ambient temperature and then heated to 85 °C. After 2 hours, the mixture was cooled and poured onto ice-water. The precipitate was filtered and dried to give the title compound (0.72 g, 43percent) as a yellow solid.LRMS (m/z): 157 (M-1 )To a solution of 5-fluoro-2-hydroxypyridine (200 mg, 1.77 mmol) in concentrated sulfuric acid (900 μl) was added, dropwise over 15 minutes, a premixed solution of concentrated sulfuric acid (900 μl) and fuming nitric acid (170 μl). The internal temperature rose by up to 28
Computed Properties
Molecular Weight:158.09
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:158.01277012
Monoisotopic Mass:158.01277012
Topological Polar Surface Area:74.9
Heavy Atom Count:11
Complexity:276
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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5-Fluoro-3-nitro-2(1H)-pyridinone
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