2-Chloro-6-methoxy-3-nitropyridine
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2-Chloro-6-methoxy-3-nitropyridine
structure -
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CAS No:
38533-61-8
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Formula:
C6H5ClN2O3
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Chemical Name:
2-Chloro-6-methoxy-3-nitropyridine
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Synonyms:
Pyridine,2-chloro-6-methoxy-3-nitro-;2-Chloro-6-methoxy-3-nitropyridine;6-Methoxy-3-nitro-2-chloropyridine
- Categories:
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CAS No:
2-Chloro-6-methoxy-3-nitropyridine Basic Attributes
188.57
188.57
253-989-8
DTXSID60191862
2933399090
Characteristics
67.9
1.9
Off-white to yellow Powder
1.4±0.1 g/cm3
78-80 °C
298.5°C at 760 mmHg
134.4±25.9 °C
1.565
Slightly soluble in water.
Safety Information
6.1
NONH for all modes of transport
3
36/37/38-44-20/21/22
26-37/39-36/37/39
Xi,Xn
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Chloro-6-methoxy-3-nitropyridine Use and Manufacturing
To a 500 mL four-neck flask were treated with THF (120 mL), MeOH (3.66 g, 115 mmol, 0.95 eq) and 2, 6-dichloro-3-nitropyridine (23 g, 120 mmol, 1 eq). After cooling down to 0 oC, 60percent NaH (6.8 g, 170 mmol, 1.7 eq) was added carefully. The mixture was stirred at this temperature for 30 minutes, then at RT for 2 hours. After completion, the mixture was quenched with water (100 mL), extracted with EA (3×150 mL), the combined organic layers were dried, concentrated and purified by silica column to give 2-chloro-6-methoxy-3-nitropyridine (12 g, 56percent). 1HNMR (300 MHz, CDCl3): G 8.37- 8.24 (m, 1 H), 7.07- 7.05 (m, 1 H), 4.15 (s, 3 H).
Computed Properties
Molecular Weight:188.57
XLogP3:1.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:187.9988697
Monoisotopic Mass:187.9988697
Topological Polar Surface Area:67.9
Heavy Atom Count:12
Complexity:173
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-6-methoxy-3-nitropyridine
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