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2-Ethoxy-4-pyridinamine

2-Ethoxy-4-pyridinamine structure

CAS No:
89943-12-4
Formula:
C7H10N2O
Chemical Name:
2-Ethoxy-4-pyridinamine
Synonyms:
4-Pyridinamine,2-ethoxy-;Pyridine,4-amino-2-ethoxy-;2-Ethoxy-4-pyridinamine;2-Ethoxy-4-aminopyridine;4-Amino-2-ethoxypyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-Ethoxy-4-pyridinamine Basic Attributes

Molecular Weight：

138.17

Exact Mass：

138.17

DSSTox ID：

DTXSID60376612

HScode：

2933399090

Characteristics

PSA：

48.1

XLogP3：

1.3

Density：

1.1±0.1 g/cm3

Melting Point：

88-89 °C

Boiling Point：

282.1°C at 760 mmHg

Flash Point：

124.4±21.8 °C

Refractive Index：

1.549

Safety Information

hazard class code：

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

2-Ethoxy-4-pyridinamine Use and Manufacturing

l) A solution of sodium (0.28 g, 12.2 mmol) in ethanol (3 mL) was added to 2-chloro-pyridin-4-ylamine (0.2 g, 1.56 mmol) in a sealed tube and the reaction was heated to 140° C. for 9 h. The cooled mixture was adjusted to pH 8-9 with 2N HCl. The mixture was extracted with 80:20 chloroform: 2-propanol, concentrated and chromatographed to yield 0.14 g (64percent) of the title compound as a white solid.

Computed Properties

Molecular Weight:138.17
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:138.079312947
Monoisotopic Mass:138.079312947
Topological Polar Surface Area:48.1
Heavy Atom Count:10
Complexity:97.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes