4-Methoxy-3-nitropyridine
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4-Methoxy-3-nitropyridine
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CAS No:
31872-62-5
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Formula:
C6H6N2O3
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Chemical Name:
4-Methoxy-3-nitropyridine
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Synonyms:
Pyridine,4-methoxy-3-nitro-;4-Methoxy-3-nitropyridine;3-Nitro-4-methoxypyridine
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CAS No:
Safety Information
NONH for all modes of transport
3
36/37/38-41-37/38-22
26-36/37/39-36-37
Xi,Xn
Irritant
P261-P280-P305 + P351 + P338
H302-H315-H318-H335
|Danger|H302 (86.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Methoxy-3-nitropyridine Use and Manufacturing
To cone. HEXAMPLE 93; Synthesis of 4-Hydroxy-4-[3-(trifluoromethy)phenyl]piperidine-1-carboxylic acid (7-methoxy-thiazolo[5, 4-b]pyridine-2-yl)-amide; Step 1: To a mixture of Step 1: 4-methoxypyridin-3-amineA solution of 4-methoxy -3-nitropyridine (100 g, 0.65 mol, Ouhe) and 10% Pd/C (10 g) in MeOH (2 L) was stirred under 50 psi of hydrogen. The reaction mixture was stirred at rt overnight. The mixture was filtered and concentrated in vacuo to afford 4-methoxypyridin-3- amine (82.1 g, quantitative) as a yellow solid.Example 26Synthesis of 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(4-methoxy-3-pyridinyl)-6-(4-morpholinyl)-1, 3, 5-triazin-2-amineThe compound was synthesized according to Method A.A mixture of 0.475 g (3.08 mmol) of To a solution of A mixture of to a solution of compound 13-1 (10.0 g, 64.9 mmol) in EtOH (400 mL) was added 10% Pd/C (w/w) (4.60 g). The reaction mixture was allowed to stir at rt under an atmosphere of ¾ for 24 hrs. Subsequently, the reaction mixture was filtered through Celite545 and the filtered cake was washed with EtOAc (100 mL x 3). The filtrate was concentrated and the residue was dried in vacuo to give crude compound 13-2 (8.0 g, 99% yield) as a dark red oil, which was used for the next step without further purification. LC-MS (ESI): m/z 125 [M+H]+.
A useful synthetic intermediate
Computed Properties
Molecular Weight:154.12
XLogP3:0.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:154.03784206
Monoisotopic Mass:154.03784206
Topological Polar Surface Area:67.9
Heavy Atom Count:11
Complexity:145
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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