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3-Methyl-4-pyridinamine

3-Methyl-4-pyridinamine structure

CAS No:
1990-90-5
Formula:
C6H8N2
Chemical Name:
3-Methyl-4-pyridinamine
Synonyms:
4-Pyridinamine,3-methyl-;3-Picoline,4-amino-;3-Methyl-4-pyridinamine;Phillips 1908;4-Amino-3-methylpyridine;3-Methyl-4-aminopyridine;4-Amino-3-picoline;NSC 52454;(3-Methylpyridin-4-yl)amine;3-Methylpyridin-4-amine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Crystals

3-Methyl-4-pyridinamine Basic Attributes

Molecular Weight：

108.14

Exact Mass：

108.14

EC Number：

217-872-5

NSC Number：

52454

DSSTox ID：

DTXSID90173676

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

0.5

Density：

0.9581 (rough estimate)

Melting Point：

108-109 °C

Boiling Point：

192.78°C (rough estimate)

Flash Point：

138.4±9.0 °C

Refractive Index：

1.5400 (estimate)

Vapor Pressure：

0.00918mmHg at 25°C

Toxicity：

Oral-rat LD50: 446mg/kg; Oral-Bird LD50: 2.40 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Transport codes：

2811

hazard class code：

23/24/25-36/37/38-34-22-20/21/22

safety instructions：

22-36/37/39-45-36-27-26

RTECS Number：

TJ5140000

Marks：

C,Xi,Xn

Storage features：

Warehouse ventilated, low temperature and dry

Hazard note：

Harmful

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

3-methyl-4-aminopyridine

3-Methyl-4-pyridinamine Use and Manufacturing

Step 2: A solution of 3-methyl-4-nitropyridine /V-oxide (30.0g, 195 mmol) and 10percent Pd-C (6.0 g) in EtOH (450 mL) was stirred at rt under H3-Methyl-4-nitropyridine 1-oxide (5.85 g) was dissolved in glacial acetic acid (115 mL) and hydrogenated in a Parr hydrogenation apparatus (catalyst: 220 mg Pt02 x 2 H20, 50 psi) at ambient temperature for 2.5 h. Then the catalyst was filtered off and the solvent was evaporated. After addition of 150 mL of water the pH was adjusted to 12 by addition of 2N NaOH. The resulting solution was extracted 10 times with 100 mL of dichloromethane (containing 5 percent methanol). The combined organic phases were dried over anhydrous sodium sulphate and evaporated to give 3.81 g (83.6percent) of 4-amino-3-methylpyridine.The crude 2-(5-chloro-2-fluorophenyl)-4-iodo-5, 6, 7, 8-tetrahydroquinazoline (130 mg, 0.35 mmol, 1 eq) was dissolved in dioxane (5 ml) and to this was added Pd(OAc)2 (4 mg, 0.02 mmol, 0.05 eq) followed by BINAP (16 mg, 0.03 mmol, 0.075 eq),

Computed Properties

Molecular Weight:108.14
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:108.068748264
Monoisotopic Mass:108.068748264
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:72.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Methyl-4-pyridinamine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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3-Methyl-4-aminopyridine

CAS No.: 1990-90-5

Content: 99.00%

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shanghai jinghui industrial co.ltd Contact Supplier

CN
4 YRS

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Trader Supplier of Fluorine containing fine chemicals Pharmaceutical

3-Methyl-4-aminopyridine 99% colorless liquid JINGHUI

CAS No.: 1990-90-5

Content: 99%

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