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Lodamin

Lodamin structure

CAS No:
129298-91-5
Formula:
C19H28ClNO6
Chemical Name:
Lodamin
Synonyms:
Carbamic acid,N-(2-chloroacetyl)-,(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;Carbamic acid,(chloroacetyl)-,5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester,[3R-[3α,4α(2R*,3R*),5β,6β]]-;Carbamic acid,(chloroacetyl)-,(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;1-Oxaspiro[2.5]octane,carbamic acid deriv.;AGM 1470;TNP 470;NSC 642492;O-Chloroacetylcarbamoylfumagillol;Lodamin;333999-83-0
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.

Lodamin Basic Attributes

Molecular Weight：

401.88

Exact Mass：

401.88

Characteristics

PSA：

89.69000

XLogP3：

1.45

Density：

1.26±0.1 g/cm3(Predicted)

Refractive Index：

1.535

Water Solubility：

DMSO: >15mg/mL

Storage Conditions：

Store at -20°C

Specific rotation：

D24 -46.6° (c = 0.44 in CHCl3)

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Lodamin Use and Manufacturing

TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.

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