3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
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![3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/215b92b42c87490faf48404ddde05fa1.png "3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide")
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
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CAS No:
409351-28-6
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Formula:
C18H19N3O2S
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Chemical Name:
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
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Synonyms:
VU0152100;3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide;VU 152100;3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
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CAS No:
Description
VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.IC50 Value: 380 ± 93 nM (EC50) [1]Target: M4 mAChRin vitro: VU0152100 was selective for M4 relative to M1, M2, M3, and M5. VU0152100 dose-dependently potentiated the response to an EC20 concentration of ACh with EC50 values of 1.9 ± 0.2 μM, and increased the maximal response to ACh to approximately 130%. VU0152100 (10 μM) also enhanced the potency of ACh to induce GIRK-mediated thallium flu
3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide Basic Attributes
342.4353
341.12000
DTXSID40357702
Safety Information
UN 2811 6.1 / PGIII
3
25-36
26-45
T
P301 + P310-P305 + P351 + P338
H301-H319
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Computed Properties
Molecular Weight:341.4
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:341.11979803
Monoisotopic Mass:341.11979803
Topological Polar Surface Area:106
Heavy Atom Count:24
Complexity:442
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridinecarboxamide
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