 Home > Encyclopedia > Anakinra

Anakinra

Anakinra structure

CAS No:
143090-92-0
Formula:
C20H23N5O7S2
Chemical Name:
Anakinra
Synonyms:
Anakinra;Kineret;Unii-9013duq28k;Interleukin1 receptor antagonist (huMan isoforM x reduced),N2-L-Methionyl- (9CI);human interleukin-1 receptor antagonist (IL-1Ra)
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

Anakinra was launched in the US as a new daily subcutaneous injection therapy for the reduction of signs and symptoms of moderately to severely active rheumatoid arthritis (RA) in adults who have failed to respond to one or more disease-modifying antirheumatic drugs. Anakinra, N2-L-methionylinterleukin-1 receptor antagonist (human isoform x reduced), is the first recombinant non-glycosylated human IL-1 receptor antagonist (IL-lra).

Anakinra is a recombinant interleukin-1 (IL-1) receptor antagonist that has antiinflammatory and immunomodulatory actions and is used in the therapy of rheumatoid arthritis and other inflammatory arthritides. Anakinra is associated with a low rate of serum enzyme elevations during therapy and with rare instances of clinically apparent, acute liver injury.|A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.

Anakinra Basic Attributes

Molecular Weight：

509.562

Exact Mass：

509.10389 g/mol

ATC Code：

L04AC03|L - Antineoplastic and immunomodulating agents

Characteristics

PSA：

227 Å²

Toxicity

Hepatotoxicity：

In large registration trials, ALT elevations occurred in

Drug Information

Drug Indication：

Rheumatoid Arthritis (RA)Kineret is indicated in adults for the treatment of the signs and symptoms of RA in combination with methotrexate, with an inadequate response to methotrexate alone.Periodic fever syndromesKineret is indicated for the treatment of the following autoinflammatory periodic fever syndromes in adults, adolescents, children and infants aged 8 months and older with a body weight of 10 kg or above:Cryopyrin-Associated Periodic Syndromes (CAPS)Kineret is indicated for the treatment of CAPS, including:Neonatal-Onset Multisystem Inflammatory Disease (NOMID) / Chronic Infantile Neurological, Cutaneous, Articular Syndrome (CINCA)Muckle-Wells Syndrome (MWS)Familial Cold Autoinflammatory Syndrome (FCAS)Familial Mediterranean Fever (FMF)Kineret is indicated for the treatment of Familial Mediterranean Fever (FMF). Kineret should be given in combination with colchicine, if appropriate.Still's DiseaseKineret is indicated in adults, adolescents, children and infants aged 8 months and older with a body weight of 10 kg or above for the treatment of Still's disease, including Systemic Juvenile Idiopathic Arthritis (SJIA) and Adult-Onset Still's Disease (AOSD), with active systemic features of moderate to high disease activity, or in patients with continued disease activity after treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or glucocorticoids.Kineret can be given as monotherapy or in combination with other anti-inflammatory drugs and disease-modifying antirheumatic drugs (DMARDs).|Treatment of chronic idiopathic arthritis (including rheumatoid arthritis, psoriatic arthritis, ankylosing, Treatment of cryopyrin-associated periodic syndromes (CAPS)

LiverTox Summary：

Drug Classes：

Antirheumatic Agents

MeSH：

Drugs that are used to treat RHEUMATOID ARTHRITIS. (See all compounds classified as Antirheumatic Agents.)

MeSH Entry Terms：

Anakinra

Anakinra Use and Manufacturing

Uses

Anti-inflammatory (nonsteroidal); suppressant (inflammatory bowel disease).

Use Classification：

Human drugs -> Kineret -> EMA Drug Category|Immunosuppressants -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:509.6
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:509.10389044
Monoisotopic Mass:509.10389044
Topological Polar Surface Area:227
Heavy Atom Count:34
Complexity:961
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Anakinra

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

anakinra

CAS No.: 143090-92-0

Content: 99.00%

Inquiry