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Apricitabine

Apricitabine structure

CAS No:
160707-69-7
Formula:
C8H11N3O3S
Chemical Name:
Apricitabine
Synonyms:
2(1H)-Pyrimidinone,4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-;2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-,(2R-cis)-;1,3-Oxathiolane,2(1H)-pyrimidinone deriv.;4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone;(-)-BCH 10652;BCH 10618;SPD 754;AVX 754;Apricitabine;(-)-2′-Deoxy-3′-oxa-4′-thiocytidine
Categories:
Biochemical Engineering > Saccharides

Description

Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki=0.08 μM), as well as inhibits DNA polymerases α, β, and γ with Ki value of 300 μM, 12 μM, and 112.25 μM, respectively[1]. Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection[2].

Apricitabine has been used in trials studying the treatment of HIV Infections.|Apricitabine is a cytidine analogue and nucleoside reverse transcriptase inhibitor (NRTI) with anti-HIV activity. Apricitabine is effective against nucleoside-resistant HIV.

Apricitabine Basic Attributes

Molecular Weight：

229.26

Exact Mass：

229.26

UNII：

K1YX059ML1

DSSTox ID：

DTXSID60166974

NCI Thesaurus Code：

C79871

Characteristics

PSA：

113

XLogP3：

-1.35

Density：

1.73

Boiling Point：

475.4±55.0 °C(Predicted)

Flash Point：

241.3±31.5 °C

Refractive Index：

1.755

Drug Information

Mechanism of Action：

Apricitabine is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs work by blocking reverse transcriptase, a protein that HIV needs to make more copies of itself.

MeSH Entry Terms：

apricitabine

Computed Properties

Molecular Weight:229.26
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:229.05211239
Monoisotopic Mass:229.05211239
Topological Polar Surface Area:113
Heavy Atom Count:15
Complexity:331
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Decarboxylated AdoMet Formula

22365-13-5
2′-Deoxy-6-thioinosine Formula

2239-64-7
2,2'-Anhydro-5-methyluridine Formula

22423-26-3
Quercetin 3-glucuronide Structure

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1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one Structure

22882-02-6
What is Sucrose

57-50-1
What is C18Dihydroceramide

2304-80-5

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Guide of Apricitabine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

Apricitabine

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