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Atipamezole

Atipamezole structure

CAS No:
104054-27-5
Formula:
C14H16N2
Chemical Name:
Atipamezole
Synonyms:
1H-Imidazole,5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-;1H-Imidazole,4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-;5-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole;MPV 1248;Atipamezole
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

Atipamezole is a synthetic α2 adrenoceptor antagonistused to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been undergone research as a potential anti-Parkinsonian drug for humans.

Atipamezole Basic Attributes

Molecular Weight：

212.29

Exact Mass：

212.29

EC Number：

1806241-263-5

UNII：

03N9U5JAF6

DSSTox ID：

DTXSID2049135

Characteristics

PSA：

28.7

XLogP3：

Appearance：

white to brown

Density：

1.115±0.06 g/cm3(Predicted)

Boiling Point：

367.1±11.0 °C(Predicted)

Flash Point：

178.0±5.7 °C

Refractive Index：

1.595

Water Solubility：

DMSO: ≥30mg/mL

Storage Conditions：

room temp

Vapor Pressure：

2.95E-05mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

For the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs.

MeSH：

Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Antagonists.)

MeSH Entry Terms：

1H-imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-

Atipamezole Use and Manufacturing

Antagonist (α2-receptor).

Computed Properties

Molecular Weight:212.29
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:212.131348519
Monoisotopic Mass:212.131348519
Topological Polar Surface Area:28.7
Heavy Atom Count:16
Complexity:237
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes