5-AMINO-2-BROMO-4-METHYLANISOLE

N-Bromosuccinimide (0.80 g, 4.50 mmol) was added portionwise over a 1 h period to an ice-chilled solution of 5-methoxy-2-methylaniline (0.62 g, 4.50 mmol) in chloroform (10 mL). The reaction mixture was then stirred at 5-10 °C for 4 h, before it was allowed to warm at room temperature. The mixture was then washed with sodium hydroxide (2 M, 10 mL) and water (2.x.20 mL), dried over anhydrous sodium sulfate and filtered. The solvent was evaporated and the residue was chromatographed (silica gel, dichloromethane) to afford 4, 6-dibromo-5-methoxy-2-methylaniline (0.12 g, 9percent) as an orange liquid.

Molecular Weight:216.07
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:214.99458
Monoisotopic Mass:214.99458
Topological Polar Surface Area:35.2
Heavy Atom Count:11
Complexity:131
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes