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Senicapoc

Senicapoc structure

CAS No:
289656-45-7
Formula:
C20H15F2NO
Chemical Name:
Senicapoc
Synonyms:
Benzeneacetamide,4-fluoro-α-(4-fluorophenyl)-α-phenyl-;4-Fluoro-α-(4-fluorophenyl)-α-phenylbenzeneacetamide;ICA 17043;Senicapoc;2,2-Bis(4-fluorophenyl)-2-phenylacetamide
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.

Senicapoc Basic Attributes

Molecular Weight：

323.34

Exact Mass：

323.34

UNII：

TS6G201A6Q

DSSTox ID：

DTXSID60276906

HScode：

2924299090

Characteristics

PSA：

43.1

XLogP3：

4.1

Density：

1.25g/cm3

Melting Point：

180-181 °C @ Solvent: Hexane, Dichloromethane

Boiling Point：

460.7°C at 760 mmHg

Flash Point：

232.4ºC

Refractive Index：

1.594

Vapor Pressure：

1.14E-08mmHg at 25°C

Drug Information

Drug Indication：

Investigated for use/treatment in anemia (sickle cell) and asthma.

MeSH Entry Terms：

bis(4-fluorophenyl)phenylacetamide

Senicapoc Use and Manufacturing

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

Computed Properties

Molecular Weight:323.3
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:323.11217043
Monoisotopic Mass:323.11217043
Topological Polar Surface Area:43.1
Heavy Atom Count:24
Complexity:397
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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