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Beraprost

Beraprost structure

CAS No:
88430-50-6
Formula:
C24H30O5
Chemical Name:
Beraprost
Synonyms:
1H-Cyclopenta[b]benzofuran-5-butanoic acid,2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-;1H-Cyclopenta[b]benzofuran-5-butanoic acid,2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-;2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid;Beraprost;ML 1229;MDL 201229
Categories:
Biochemical Engineering > Inflammation Mediators

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Beraprost Basic Attributes

Molecular Weight：

398.49

Exact Mass：

398.49

EC Number：

1312995-182-4

DSSTox ID：

DTXSID7049136

ATC Code：

B - Blood and blood forming organs

Characteristics

PSA：

86.99000

XLogP3：

2.87

Density：

1.3±0.1 g/cm3

Boiling Point：

572.1±50.0 °C at 760 mmHg

Flash Point：

193.1±23.6 °C

Refractive Index：

1.625

Drug Information

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

4-(1,2,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyloct-6-yne-1-enyl)-5-cyclopenta(b)benzofuranyl)butyrate

Beraprost Use and Manufacturing

Methods of Manufacturing

Alcohol (I) is oxidatively dehydrogenated with dimethyl sulfoxide-dicyclohexylcarbodiimide (DCC) in anhydrous benzene and pyridine to give aldehyde (Ⅱ); then under the protection of argon, immediately add the phosphide (Ⅲ) ) And sodium hydride in ethylene glycol dimethyl ether, condensation to obtain compound (IV), a yield of 80%. (IV) Reduction with lithium aluminum hydride to obtain 44% of compound (V), and finally hydrolysis to obtain beraprost.

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Computed Properties

Molecular Weight:398.5
XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:398.20932405
Monoisotopic Mass:398.20932405
Topological Polar Surface Area:87
Heavy Atom Count:29
Complexity:659
Undefined Atom Stereocenter Count:6
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1,2-Dimethoxyethane

Argon

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Beraprostum

CAS No.: 88430-50-6

Grade: Industrial Grade

Content: 98%

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Jinan topfull chemical co.,ltd Contact Supplier

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Trader Supplier of 3-(1-Naphthoyl)indole

Beraprost cas 88430-50-6 scientific research use

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CAS No.: 88430-50-6

Grade: Pharmaceutical Grade

Content: 99%

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Guide of Beraprost

Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Material
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Beraprost

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