Argon

39.95

39.96240

231-147-0

67XQY1V3KH

0154

1006|1951

DTXSID3052482|DTXSID30435907|DTXSID90745913

Colorless monatomic gas

2804210000

0

0.94

Argon appears as a colorless odorless noncombustible gas. Heavier than air and can asphyxiate by displacement of air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket . If liquefied, contact of the very cold liquid with water may cause violent boiling. If the water is hot, there is the possibility that a liquid "superheat" explosion may occur. Contacts with water in a closed container may cause dangerous pressure to build.

3.424 g/cm³

-189.2 °C

-185.9 °C

Solubility in water, ml/100ml at 20°C: 3.4

Keep container tightly closed in a dry and well-ventilated place. Contents under pressure.

1.38 (21 °C, vs air)

Only asphyxiating toxicity reviews

Non-flammable; non-toxic, but suffocating

Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. /Argon, compressed; Argon, refrigerated liquid/

Odorless

Tasteless

A noble gas characterized by an electronic structure in which the outer p subshell is entirely filled|Naturally occurring argon is a mixture of three isotopes. Seventeen radioactive isotopes are now known to exist.|It is not known to combine chemically with any element, but forms a stable clathrate with beta-hydroquinone.|Will form compounds with highly electromagnetic elements such as O, F, Cl.|For more Other Experimental Properties (Complete) data for Argon, Elemental (8 total), please visit the HSDB record page.|Liquid: normal BP: -185.87 °C, density (normal BP): 1393.9 kg/cu m; at triple point: 1415 kg/cu m

No rapid reaction with air. No rapid reaction with water.

Not Chemically Reactive

These substances undergo no chemical reactions under any known circumstances. They are nonflammable, noncombustible and nontoxic. They can asphyxiate.|These substances undergo no chemical reactions under any known circumstances. They are nonflammable, noncombustible and nontoxic. They can asphyxiate. Contact of very cold liquefied gas with water may result in vigorous or violent boiling of the product and extremely rapid vaporization due to the large temperature differences involved. If the water is hot, there is the possibility that a liquid "superheat" explosion may occur. Pressures may build to dangerous levels if liquid gas contacts water in a closed container [Handling Chemicals Safely 1980].

The gas is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.

Liquid (normal BP): 6469 J/mol; Solid: (triple pt): 7.785 kJ/mol.

Critical temperature: 150.86 K; critical pressure: 4898 kPa

2.2

UN 1006 2.2

-

38

CF2300000

Warehouse ventilated, low temperature and dry; light loading and unloading

High temperature explosion of steel cylinder

Stable. Inert.

P41, P403

H280

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Excerpt from ERG Guide 121 [Gases - Inert]: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Not combustible. Heating will cause rise in pressure with risk of bursting.

|Warning|H280 (65.47%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P282, P315, P336, P403, and P410+P403|Aggregated GHS information provided by 589 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P410+P40, and 410+P403|Aggregated GHS information provided by 78 companies from 2 notifications to the ECHA C&L Inventory.|H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

Excerpt from ERG Guide 121 [Gases - Inert]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids or solids. (ERG, 2016)|Personnel protection: Wear appropriate chemical protective gloves and goggles. /Argon, compressed; Argon, refrigerated liquid/|Eye protection: Safety glasses.|For prolonged or repeated contact use protective gloves.|Respiratory protection is not required. Where protection is desired, use multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. /Argon, compressed; Argon, refrigerated liquid/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Argon, compressed; Argon, refrigerated liquid/|If material involved in fire: Do not use water on material itself. /Argon, refrigerated liquid/|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.

Personal precautions: Avoid breathing vapors, mist or gas. Environmental precautions: No special environmental precautions required. Methods for cleaning up: Wipe up with absorbent material (e.g. cloth, fleece).

If material not involved in fire: Do not use water on material itself. /Argon, refrigerated liquid/|If material not involved in fire: Attempt to stop leak it without undue personnel hazard. /Argon, compressed; Argon, refrigerated liquid/|Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. /Argon, compressed; Argon, refrigerated liquid/|If breathed in, move person into fresh air. If not breathing give artificial respiration In case of skin contact: Wash off with soap and plenty of water. In case of eye contact: Flush eyes with water as a precaution. If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water.

/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. /Argon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Fire or Explosion: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. /Argon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering. /Argon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids or solids. /Argon, refrigerated liquid (cryogenic liquid)/|For more DOT Emergency Guidelines (Complete) data for Argon, Elemental (16 total), please visit the HSDB record page.

Personal protection: self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid.

Fireproof if in building. Keep in a well-ventilated room.

On loss of containment this substance can cause suffocation by lowering the oxygen content of the air in confined areas.

Asphyxiation. The liquid may cause frostbite.

Use ventilation.

Cold-insulating gloves. Protective clothing.

Wear safety goggles or face shield.

Concentration in atmosphere: 93.40 ppm by volume|The atmosphere of Mars contains 1.6% of argon-40 and 5 ppm of argon-36.

Stable naturally occurring isotopes (mass numbers): 36 (0.377%); 38 (0.063%); 40 (99.600%) ... Abundance in igneous rock of the earth's crust: 4X10-2 ppm by weight ... The isotope As(40) is always found in minerals containing potassium, since it is a product of K(40) decay.|In the earth's atmosphere, noble gases make up about 1% ... argon is their major component.|The atmosphere of Mars contains 1.6% of argon-40 and 5 ppm of argon-36.

GROUNDWATER: Argon concentrations ranged from 13.1 to 17.2 micromoles/L (median 15.5 micromoles/L) in samples of groundwater from Orangeburg County, SC, collected in November 1997(1). Argon was reported at a concentration range of 0.7515 to 1.0923 mg/L in ground water samples taken at Mirror Lake, New Hampshire in 1991 and 1992(2).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of argon is 1 to 99; the data may be greatly underestimated(1).

The argon plasma coagulator is a device used for noncontact thermal coagulation of tissue. The device was first used in open and laparoscopic surgical procedures and in 1991 was adapted for use in endoscopy. Since then, argon plasma coagulation has expanded its clinical applications in the treatment of various gastrointestinal conditions. ...

Excerpt from ERG Guide 121 [Gases - Inert]: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Keep victim calm and warm. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Clothing frozen to the skin should be thawed before being removed. In case of contact with liquefied gas, thaw frosted parts with lukewarm water. Keep victim calm and warm. (ERG, 2016)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Simple asphyxiants and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary ... . Use rapid rewarming techniques if frostbite occurs ... . /Simple asphyxiants and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Treat seizures with diazepam or lorazepam ... . /Simple asphyxiants and related compounds/

/SIGNS AND SYMPTOMS/ Contact with the liquid will cause frostbite./Argon, refrigerated liquid/|/CASE REPORTS/ A 31-year-old engineer was found dead in a reaction vessel (diameter 0.8 m, height 1.8 m) of a bulb factory some minutes after he had entered it for repair work. Resuscitation attempts with artificial respiration were unsuccessful. Despite autopsy and usual toxicological analyses, no cause of death could be found. Since in the normal production process, argon was used as a protecting gas, the possibility of suffocation in an argon atmosphere was investigated. This was rendered more difficult because of the natural content of 0.93 vol.% argon in air and since the excessive argon could have been removed by the resuscitation attempts. Gas samples from larynx, esophagus, bronchi, and stomach, separated blood samples from both ventricles of the heart and from the vena iliaca externa as well as tissue samples from lung and liver were collected during autopsy into headspace vials in such a way that the loss of gas and a dilution by surrounding air was avoided as far as possible. The samples were analyzed by headspace GC-MS. The abundance of Ar+ (m/z = 40) was used for quantification with N2(2+) (m/z = 14) as internal standard. The following argon concentrations were measured (mean values, case under investigation/comparison cases): gas from larynx 1.79/0.96 vol.%, stomach gas 1.58/0.89 vol.%, heart blood (left ventricle) 7.2/2.7 microg/mL, heart blood (right ventricle) 5.8/2.7 microg/mL, blood from vena iliaca externa 3.6/2.7 microg/mL. A clearly increased concentration was also found in lung tissue, whereas in liver tissue no significant difference in comparison to other cases was measured. From the results, it follows that the deceased inhaled an increased amount of argon a short time before death. The concentrations are consistent with asphyxia and subsequent resuscitation attempts. ...|/CASE REPORTS/ ... /A/ fatality from argon gas emboli during prostate cryosurgery /is reported/. The decedent underwent cryotherapy for prostate carcinoma using cryoablation probes which were cooled with argon and nitrous oxide and warmed with helium. Minutes into the procedure he experienced sudden cardiovascular collapse and could not be resuscitated. Postmortem examination was performed ... . Collection of tissues and blood samples had to be conducted carefully to capture suspected noble gases, argon, and helium. Specimens were submitted ... for toxicological examination and for evaluation of the composition of the gas retrieved from the vascular system. Gas chromatography mass spectrometric analyses confirmed argon in blood, brain, liver, and gas retrieved from the aorta. These samples had significant argon compared with room air also sent for comparison. The manner of death was accident. ...

Argon

The substance can be absorbed into the body by inhalation.

Dizziness. Lethargy. Headache. Suffocation.

ON CONTACT WITH LIQUID: FROSTBITE.

ON CONTACT WITH LIQUID: FROSTBITE.

Grade: Technical, highest purity (99.9995%)

Argon: ACTIVE|Argon is a noble gas, i.e. monatomic, non-polar|Method of purification: (1) Highly purified argon is obtained by passing the gas through a bed of titanium at 850 °C. (2) Synthetic zeolite molecular sieves separate oxygen from argon to give high purity gas.|Obtained commercially from the atmosphere by distillation-liquefaction process

Food additives|Human drugs -> Rare disease (orphan)

Food Additives -> PROPELLANT;