4-Chloro-2,5-dimethoxybenzaldehyde

To a mixture of compound 4 (1.0 g, 5.79 mmol) and hexamethylenetetramine (893mg, 6.37 mmol) in THF, TFA (12.89 mg, 113 mmol) was added slowly. The reactionmixture was then refluxed for 2 hours. After that, the hot reaction liquid was pouredinto ice and its pH was adjusted to 7 with NaHCO3 powder. The mixture was extractedwith ethyl acetate and the organic phase was collected, washed with brine, dried overNa2SO4, and concentrated under reduced pressure to get the reaction crude. Thereaction crude was then purified with silica gel to give 543 mg compound 5 as a whitesolid in 47 percent yield.

Molecular Weight:200.62
XLogP3:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.0240218
Monoisotopic Mass:200.0240218
Topological Polar Surface Area:35.5
Heavy Atom Count:13
Complexity:174
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes