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5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone

5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone structure

CAS No:
530084-79-8
Formula:
C18H16BrNO3
Chemical Name:
5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone
Synonyms:
2(1H)-Quinolinone,5-[(1R)-2-bromo-1-hydroxyethyl]-8-(phenylmethoxy)-;5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone;8-(Benzyloxy)-5-((1R)-2-bromo-1-hydroxyethyl)quinolin-2(1H)-one;8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolin-2-one;5-(2-Bromo-(R)-1-hydroxyethyl)-8-benzyloxy-2(1H)-quinolinone;(R)-8-Benzyloxy-5-(2-bromo-1-hydroxyethyl)carbostyril;(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one;(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one;2(1H)-Quinolinone 5-[(1R)-2-bromo-1-hydroxyethyl]-8-(phenylmethoxy)-;(R)-8-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Light Brown Solid

5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone Basic Attributes

Molecular Weight：

374.22854

Exact Mass：

374.23

EC Number：

610-932-5

DSSTox ID：

DTXSID70468138

HScode：

2933790090

Characteristics

PSA：

58.6

XLogP3：

2.7

Density：

1.5±0.1 g/cm3

Boiling Point：

595.8°C at 760 mmHg

Flash Point：

314.1±30.1 °C

Refractive Index：

1.649

Safety Information

Precautionary statement(s)：

P280, P305+P351+P338, P310

Hazard Statements：

H318

GHS Classification：

|Danger|H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P273, P280, P302+P352, P305+P351+P338, P310, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone Use and Manufacturing

Methods of Manufacturing

To a mixture of tetrahydroffiran (1400 ml) and Bromo compound (100 g), R-methyl CBS (7.5 g) was slowly added at 25-30° C. under nitrogen atmosphere and cooled to 0-5° C., followed by the addition of Boron Dimethyl Sulfide complex (24.3 g) at 0-10° C. The reaction mass was stirred for 1-2 hr at 0-10° C. The progress of the reaction was monitored by HPLC. After the completionthe reaction, methanol (100 ml) was slowly added to the reaction mass for 30 minutes and stirred for 15 minutes0-10° C. The contents were distilled under vacuum attemperature of 40-45° C. and cooled to 25-30° C. The cooled reaction mixture was slowly added to hydrochloric acid solution at 25-30° C. and stirred for 1-2 hours at the same temperature. The resulted solid was filtered, washed with water (300 ml) and dried at 65-70° C. for 8 hours. percent Yield:95percent

Uses

Used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Computed Properties

Molecular Weight:374.2
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:373.03136
Monoisotopic Mass:373.03136
Topological Polar Surface Area:58.6
Heavy Atom Count:23
Complexity:436
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone

CAS No.: 530084-79-8

Content: 99.00%

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Hangzhou Royalchem Co.,LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Pharmaceutical intermediates

(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one RC07976

Unit Price: $1 /KG EXW

CAS No.: 530084-79-8

Grade: Industrial Grade

Content: 99%

Inquiry
Changzhou Guiding Bio-tech. Co.,Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Fine chemical products,Pharmaceutical starting materials

8-benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone

CAS No.: 530084-79-8

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Guide of 5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

5-[(1R)-2-Bromo-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone

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