1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL
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1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL
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CAS No:
56108-27-1
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Formula:
C19H20F3NO
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Chemical Name:
1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL
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Synonyms:
1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL;1-BENZYL-4-HYDROXY-4-(3-TRIDLUOROTOLYL)PIPERIDINOL;1-(Phenylmethyl)-4-(3-(trifluoromethyl)phenyl)-4-piperidinol;1-Benzyl-4-hydroxy-4-(3-trifluorotolyl)pi-peridine;1-Benzyl-4-（3-trifuoromethyl)-phenyl-4-piperdinol;1-Benzyl-4-(3-(trifluoromethyl)phenyl)piperidin-4-ol;N-Benzyl-4-（3-trifuoromethyl)-phenyl-4-piperidinol;1-Benzyl-4-(3-trifluoromethyl)phenyl-4-piperdinol
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CAS No:
1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL Use and Manufacturing
Add benzylamine and methyl acrylate under reflux to generate N, N-bis(β-methylpropionate)benzylamine, which is then cyclized and converted into hydrochloride under the action of sodium methoxide to obtain 1-benzyl -3-Methoxycarbonyl-4-piperidone hydrochloride, the latter is hydrolyzed with hydrochloric acid and decarboxylated to obtain 1-benzyl-4-piperidone, which is then combined with m-bromobenzotrifluoride and metal magnesium (Grignard reagent ) Reaction to obtain 1-benzyl-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine magnesium bromide, which is finally obtained by hydrolysis with hydrochloric acid.
Intermediate of trifluoperidine hydrochloride.
Computed Properties
Molecular Weight:335.4
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:335.14969875
Monoisotopic Mass:335.14969875
Topological Polar Surface Area:23.5
Heavy Atom Count:24
Complexity:398
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL
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