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Carboxyethylgermanium sesquioxide

Carboxyethylgermanium sesquioxide structure

CAS No:
12758-40-6
Formula:
C6H10Ge2O7
Chemical Name:
Carboxyethylgermanium sesquioxide
Synonyms:
Propanoic acid,3,3′-(1,3-dioxo-1,3-digermoxanediyl)bis-;3,3′-(1,3-Dioxo-1,3-digermoxanediyl)bis[propanoic acid];Carboxyethylgermanium sesquioxide;2-(Carboxyethyl)germanium sesquioxide;Ge 132;SK 818;Proxigermanium;β-Carboxyethylgermanium sesquioxide;Arlamol GEO;Rapagermanium;Serocion;Repagermanium;NSC 267004;3-[[2-Carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid;27031-31-8;31434-91-0;69992-83-2;83172-76-3;122402-75-9;1576423-70-5
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Propagermanium, the first organogermanium compound marketed as a pharmaceutical, is indicated for the oral treatment of chronic hepatitis B. Propagermanium is reported to enhance production of interferon α/β in virus infected mice and in human peripheral blood mononuclear cells but does not inhibit the growth of various DNA or RNA viruses in vitro. Therefore, enhancement of the host immune system against virus infection was proposed to be responsible for its antiviral activity. Propagermanium a

Propagermanium is an organogermanium compound.

Carboxyethylgermanium sesquioxide Basic Attributes

Molecular Weight：

339.42

Exact Mass：

339.42

EC Number：

235-800-0

NSC Number：

267004

DSSTox ID：

DTXSID9065316

HScode：

2934999090

Characteristics

PSA：

118

XLogP3：

0.01480

Melting Point：

270 °C (decomp)

Water Solubility：

Slightly soluble in water.

Toxicity：

LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz)

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36/37/39

RTECS Number：

UA2459750

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons. (See all compounds classified as Interferon Inducers.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

3-oxygermylpropionic acid polymer

Carboxyethylgermanium sesquioxide Use and Manufacturing

Uses

antifungal and antiseptic

Manufacturing Info：

Propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis-: ACTIVE

Use Classification：

Human drugs -> Rare disease (orphan)|Cosmetics -> Skin conditioning

Computed Properties

Molecular Weight:339.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:339.8859062
Monoisotopic Mass:341.8850082
Topological Polar Surface Area:118
Heavy Atom Count:15
Complexity:259
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Carboxyethylgermanium sesquioxide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Carboxyethylgermanium sesquioxide

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